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Pregled bibliografske jedinice broj: 1259761

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Conti, David V.; Darst, Burcu F.; Moss, Lilit C.; Saunders, Edward J.; Sheng, Xin; Chou, Alisha; Schumacher, Fredrick R.; Olama, Ali Amin Al; Benlloch, Sara; Dadaev, Tokhir et al.
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction // Nature genetics, 53 (2021), 1; 65-75 doi:10.1038/s41588-020-00748-0 (međunarodna recenzija, članak, znanstveni)

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Naslov
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Autori
Conti, David V. ; Darst, Burcu F. ; Moss, Lilit C. ; Saunders, Edward J. ; Sheng, Xin ; Chou, Alisha ; Schumacher, Fredrick R. ; Olama, Ali Amin Al ; Benlloch, Sara ; Dadaev, Tokhir ; Brook, Mark N. ; Sahimi, Ali ; Hoffmann, Thomas J. ; Takahashi, Atushi ; Matsuda, Koichi ; Momozawa, Yukihide ; Fujita, Masashi ; Muir, Kenneth ; Lophatananon, Artitaya ; Wan, Peggy ; Le Marchand, Loic ; Wilkens, Lynne R. ; Stevens, Victoria L. ; Gapstur, Susan M. ; Carter, Brian D. ; Schleutker, Johanna ; Tammela, Teuvo L. J. ; Sipeky, Csilla ; Auvinen, Anssi ; Giles, Graham G. ; Southey, Melissa C. ; MacInnis, Robert J. ; Cybulski, Cezary ; Wokołorczyk, Dominika ; Lubiński, Jan ; Neal, David E. ; Donovan, Jenny L. ; Hamdy, Freddie C. ; Martin, Richard M. ; Nordestgaard, Børge G. ; Nielsen, Sune F. ; Weischer, Maren ; Bojesen, Stig E. ; Røder, Martin Andreas ; Iversen, Peter ; Batra, Jyotsna ; Chambers, Suzanne ; Moya, Leire ; Horvath, Lisa ; Clements, Judith A. ; Tilley, Wayne ; Risbridger, Gail P. ; Gronberg, Henrik ; Aly, Markus ; Szulkin, Robert ; Eklund, Martin ; Nordström, Tobias ; Pashayan, Nora ; Dunning, Alison M. ; Ghoussaini, Maya ; Travis, Ruth C. ; Key, Tim J. ; Riboli, Elio ; Park, Jong Y. ; Sellers, Thomas A. ; Lin, Hui-Yi ; Albanes, Demetrius ; Weinstein, Stephanie J. ; Mucci, Lorelei A. ; Giovannucci, Edward ; Lindstrom, Sara ; Kraft, Peter ; Hunter, David J. ; Penney, Kathryn L. ; Turman, Constance ; Tangen, Catherine M. ; Goodman, Phyllis J. ; Thompson, Ian M. ; Hamilton, Robert J. ; Fleshner, Neil E. ; Finelli, Antonio ; Parent, Marie-Élise ; Stanford, Janet L. ; Ostrander, Elaine A. ; Geybels, Milan S. ; Koutros, Stella ; Freeman, Laura E. Beane ; Stampfer, Meir ; Wolk, Alicja ; Håkansson, Niclas ; Andriole, Gerald L. ; Hoover, Robert N. ; Machiela, Mitchell J. ; Sørensen, Karina Dalsgaard ; Borre, Michael ; Blot, William J. ; Zheng, Wei ; Yeboah, Edward D. ; Mensah, James E. ; Lu, Yong-Jie ; Zhang, Hong-Wei ; Feng, Ninghan ; Mao, Xueying ; Wu, Yudong ; Zhao, Shan-Chao ; Sun, Zan ; Thibodeau, Stephen N. ; McDonnell, Shannon K. ; Schaid, Daniel J. ; West, Catharine M. L. ; Burnet, Neil ; Barnett, Gill ; Maier, Christiane ; Schnoeller, Thomas ; Luedeke, Manuel ; Kibel, Adam S. ; Drake, Bettina F. ; Cussenot, Olivier ; Cancel-Tassin, Géraldine ; Menegaux, Florence ; Truong, Thérèse ; Koudou, Yves Akoli ; John, Esther M. ; Grindedal, Eli Marie ; Maehle, Lovise ; Khaw, Kay-Tee ; Ingles, Sue A. ; Stern, Mariana C. ; Vega, Ana ; Gómez-Caamaño, Antonio ; Fachal, Laura ; Rosenstein, Barry S. ; Kerns, Sarah L. ; Ostrer, Harry ; Teixeira, Manuel R. ; Paulo, Paula ; Brandão, Andreia ; Watya, Stephen ; Lubwama, Alexander ; Bensen, Jeannette T. ; Fontham, Elizabeth T. H. ; Mohler, James ; Taylor, Jack A. ; Kogevinas, Manolis ; Llorca, Javier ; Castaño-Vinyals, Gemma ; Cannon-Albright, Lisa ; Teerlink, Craig C. ; Huff, Chad D. ; Strom, Sara S. ; Multigner, Luc ; Blanchet, Pascal ; Brureau, Laurent ; Kaneva, Radka ; Slavov, Chavdar ; Mitev, Vanio ; Leach, Robin J. ; Weaver, Brandi ; Brenner, Hermann ; Cuk, Katarina ; Holleczek, Bernd ; Saum, Kai-Uwe ; Klein, Eric A. ; Hsing, Ann W. ; Kittles, Rick A. ; Murphy, Adam B. ; Logothetis, Christopher J. ; Kim, Jeri ; Neuhausen, Susan L. ; Steele, Linda ; Ding, Yuan Chun ; Isaacs, William B. ; Nemesure, Barbara ; Hennis, Anselm J. M. ; Carpten, John ; Pandha, Hardev ; Michael, Agnieszka ; De Ruyck, Kim ; De Meerleer, Gert ; Ost, Piet ; Xu, Jianfeng ; Razack, Azad ; Lim, Jasmine ; Teo, Soo-Hwang ; Newcomb, Lisa F. ; Lin, Daniel W. ; Fowke, Jay H. ; Neslund-Dudas, Christine ; Rybicki, Benjamin A. ; Gamulin, Marija ; Lessel, Davor ; Kuliš, Tomislav ; Usmani, Nawaid ; Singhal, Sandeep ; Parliament, Matthew ; Claessens, Frank ; Joniau, Steven ; Van den Broeck, Thomas ; Gago-Dominguez, Manuela ; Castelao, Jose Esteban ; Martinez, Maria Elena ; Larkin, Samantha ; Townsend, Paul A. ; Aukim-Hastie, Claire ; Bush, William S. ; Aldrich, Melinda C. ; Crawford, Dana C. ; Srivastava, Shiv ; Cullen, Jennifer C. ; Petrovics, Gyorgy ; Casey, Graham ; Roobol, Monique J. ; Jenster, Guido ; van Schaik, Ron H. N. ; Hu, Jennifer J. ; Sanderson, Maureen ; Varma, Rohit ; McKean-Cowdin, Roberta ; Torres, Mina ; Mancuso, Nicholas ; Berndt, Sonja I. ; Van Den Eeden, Stephen K. ; Easton, Douglas F. ; Chanock, Stephen J. ; Cook, Michael B. ; Wiklund, Fredrik ; Nakagawa, Hidewaki ; Witte, John S. ; Eeles, Rosalind A. ; Kote-Jarai, Zsofia ; Haiman, Christopher A.

Izvornik
Nature genetics (1061-4036) 53 (2021), 1; 65-75

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostate cancer ; meta-analysis

Sažetak
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107, 247 cases and 127, 006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Erratum in
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Nat Genet. 2021 Mar;53(3):413. doi: 10.1038/s41588-021-00786-2. PMID: 33473200 No abstract available.



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Marija Gamulin (autor)

Avatar Url Tomislav Kuliš (autor)

Poveznice na cjeloviti tekst rada:

doi pubmed.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Conti, David V.; Darst, Burcu F.; Moss, Lilit C.; Saunders, Edward J.; Sheng, Xin; Chou, Alisha; Schumacher, Fredrick R.; Olama, Ali Amin Al; Benlloch, Sara; Dadaev, Tokhir et al.
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction // Nature genetics, 53 (2021), 1; 65-75 doi:10.1038/s41588-020-00748-0 (međunarodna recenzija, članak, znanstveni)
Conti, D., Darst, B., Moss, L., Saunders, E., Sheng, X., Chou, A., Schumacher, F., Olama, A., Benlloch, S. & Dadaev, T. (2021) Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nature genetics, 53 (1), 65-75 doi:10.1038/s41588-020-00748-0.
@article{article, author = {Conti, David V. and Darst, Burcu F. and Moss, Lilit C. and Saunders, Edward J. and Sheng, Xin and Chou, Alisha and Schumacher, Fredrick R. and Olama, Ali Amin Al and Benlloch, Sara and Dadaev, Tokhir and Brook, Mark N. and Sahimi, Ali and Hoffmann, Thomas J. and Takahashi, Atushi and Matsuda, Koichi and Momozawa, Yukihide and Fujita, Masashi and Muir, Kenneth and Lophatananon, Artitaya and Wan, Peggy and Le Marchand, Loic and Wilkens, Lynne R. and Stevens, Victoria L. and Gapstur, Susan M. and Carter, Brian D. and Schleutker, Johanna and Tammela, Teuvo L. J. and Sipeky, Csilla and Auvinen, Anssi and Giles, Graham G. and Southey, Melissa C. and MacInnis, Robert J. and Cybulski, Cezary and Woko\lorczyk, Dominika and Lubi\'{n}ski, Jan and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Nordestgaard, B\orge G. and Nielsen, Sune F. and Weischer, Maren and Bojesen, Stig E. and R\oder, Martin Andreas and Iversen, Peter and Batra, Jyotsna and Chambers, Suzanne and Moya, Leire and Horvath, Lisa and Clements, Judith A. and Tilley, Wayne and Risbridger, Gail P. and Gronberg, Henrik and Aly, Markus and Szulkin, Robert and Eklund, Martin and Nordstr\"{o}m, Tobias and Pashayan, Nora and Dunning, Alison M. and Ghoussaini, Maya and Travis, Ruth C. and Key, Tim J. and Riboli, Elio and Park, Jong Y. and Sellers, Thomas A. and Lin, Hui-Yi and Albanes, Demetrius and Weinstein, Stephanie J. and Mucci, Lorelei A. and Giovannucci, Edward and Lindstrom, Sara and Kraft, Peter and Hunter, David J. and Penney, Kathryn L. and Turman, Constance and Tangen, Catherine M. and Goodman, Phyllis J. and Thompson, Ian M. and Hamilton, Robert J. and Fleshner, Neil E. and Finelli, Antonio and Parent, Marie-\'{E}lise and Stanford, Janet L. and Ostrander, Elaine A. and Geybels, Milan S. and Koutros, Stella and Freeman, Laura E. Beane and Stampfer, Meir and Wolk, Alicja and H\aakansson, Niclas and Andriole, Gerald L. and Hoover, Robert N. and Machiela, Mitchell J. and S\orensen, Karina Dalsgaard and Borre, Michael and Blot, William J. and Zheng, Wei and Yeboah, Edward D. and Mensah, James E. and Lu, Yong-Jie and Zhang, Hong-Wei and Feng, Ninghan and Mao, Xueying and Wu, Yudong and Zhao, Shan-Chao and Sun, Zan and Thibodeau, Stephen N. and McDonnell, Shannon K. and Schaid, Daniel J. and West, Catharine M. L. and Burnet, Neil and Barnett, Gill and Maier, Christiane and Schnoeller, Thomas and Luedeke, Manuel and Kibel, Adam S. and Drake, Bettina F. and Cussenot, Olivier and Cancel-Tassin, G\'{e}raldine and Menegaux, Florence and Truong, Th\'{e}r\`{e}se and Koudou, Yves Akoli and John, Esther M. and Grindedal, Eli Marie and Maehle, Lovise and Khaw, Kay-Tee and Ingles, Sue A. and Stern, Mariana C. and Vega, Ana and G\'{o}mez-Caama\~{n}o, Antonio and Fachal, Laura and Rosenstein, Barry S. and Kerns, Sarah L. and Ostrer, Harry and Teixeira, Manuel R. and Paulo, Paula and Brand\~{a}o, Andreia and Watya, Stephen and Lubwama, Alexander and Bensen, Jeannette T. and Fontham, Elizabeth T. H. and Mohler, James and Taylor, Jack A. and Kogevinas, Manolis and Llorca, Javier and Casta\~{n}o-Vinyals, Gemma and Cannon-Albright, Lisa and Teerlink, Craig C. and Huff, Chad D. and Strom, Sara S. and Multigner, Luc and Blanchet, Pascal and Brureau, Laurent and Kaneva, Radka and Slavov, Chavdar and Mitev, Vanio and Leach, Robin J. and Weaver, Brandi and Brenner, Hermann and Cuk, Katarina and Holleczek, Bernd and Saum, Kai-Uwe and Klein, Eric A. and Hsing, Ann W. and Kittles, Rick A. and Murphy, Adam B. and Logothetis, Christopher J. and Kim, Jeri and Neuhausen, Susan L. and Steele, Linda and Ding, Yuan Chun and Isaacs, William B. and Nemesure, Barbara and Hennis, Anselm J. M. and Carpten, John and Pandha, Hardev and Michael, Agnieszka and De Ruyck, Kim and De Meerleer, Gert and Ost, Piet and Xu, Jianfeng and Razack, Azad and Lim, Jasmine and Teo, Soo-Hwang and Newcomb, Lisa F. and Lin, Daniel W. and Fowke, Jay H. and Neslund-Dudas, Christine and Rybicki, Benjamin A. and Gamulin, Marija and Lessel, Davor and Kuli\v{s}, Tomislav and Usmani, Nawaid and Singhal, Sandeep and Parliament, Matthew and Claessens, Frank and Joniau, Steven and Van den Broeck, Thomas and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Martinez, Maria Elena and Larkin, Samantha and Townsend, Paul A. and Aukim-Hastie, Claire and Bush, William S. and Aldrich, Melinda C. and Crawford, Dana C. and Srivastava, Shiv and Cullen, Jennifer C. and Petrovics, Gyorgy and Casey, Graham and Roobol, Monique J. and Jenster, Guido and van Schaik, Ron H. N. and Hu, Jennifer J. and Sanderson, Maureen and Varma, Rohit and McKean-Cowdin, Roberta and Torres, Mina and Mancuso, Nicholas and Berndt, Sonja I. and Van Den Eeden, Stephen K. and Easton, Douglas F. and Chanock, Stephen J. and Cook, Michael B. and Wiklund, Fredrik and Nakagawa, Hidewaki and Witte, John S. and Eeles, Rosalind A. and Kote-Jarai, Zsofia and Haiman, Christopher A.}, year = {2021}, pages = {65-75}, DOI = {10.1038/s41588-020-00748-0}, keywords = {prostate cancer, meta-analysis}, journal = {Nature genetics}, doi = {10.1038/s41588-020-00748-0}, volume = {53}, number = {1}, issn = {1061-4036}, title = {Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction}, keyword = {prostate cancer, meta-analysis} }
@article{article, author = {Conti, David V. and Darst, Burcu F. and Moss, Lilit C. and Saunders, Edward J. and Sheng, Xin and Chou, Alisha and Schumacher, Fredrick R. and Olama, Ali Amin Al and Benlloch, Sara and Dadaev, Tokhir and Brook, Mark N. and Sahimi, Ali and Hoffmann, Thomas J. and Takahashi, Atushi and Matsuda, Koichi and Momozawa, Yukihide and Fujita, Masashi and Muir, Kenneth and Lophatananon, Artitaya and Wan, Peggy and Le Marchand, Loic and Wilkens, Lynne R. and Stevens, Victoria L. and Gapstur, Susan M. and Carter, Brian D. and Schleutker, Johanna and Tammela, Teuvo L. J. and Sipeky, Csilla and Auvinen, Anssi and Giles, Graham G. and Southey, Melissa C. and MacInnis, Robert J. and Cybulski, Cezary and Woko\lorczyk, Dominika and Lubi\'{n}ski, Jan and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Nordestgaard, B\orge G. and Nielsen, Sune F. and Weischer, Maren and Bojesen, Stig E. and R\oder, Martin Andreas and Iversen, Peter and Batra, Jyotsna and Chambers, Suzanne and Moya, Leire and Horvath, Lisa and Clements, Judith A. and Tilley, Wayne and Risbridger, Gail P. and Gronberg, Henrik and Aly, Markus and Szulkin, Robert and Eklund, Martin and Nordstr\"{o}m, Tobias and Pashayan, Nora and Dunning, Alison M. and Ghoussaini, Maya and Travis, Ruth C. and Key, Tim J. and Riboli, Elio and Park, Jong Y. and Sellers, Thomas A. and Lin, Hui-Yi and Albanes, Demetrius and Weinstein, Stephanie J. and Mucci, Lorelei A. and Giovannucci, Edward and Lindstrom, Sara and Kraft, Peter and Hunter, David J. and Penney, Kathryn L. and Turman, Constance and Tangen, Catherine M. and Goodman, Phyllis J. and Thompson, Ian M. and Hamilton, Robert J. and Fleshner, Neil E. and Finelli, Antonio and Parent, Marie-\'{E}lise and Stanford, Janet L. and Ostrander, Elaine A. and Geybels, Milan S. and Koutros, Stella and Freeman, Laura E. Beane and Stampfer, Meir and Wolk, Alicja and H\aakansson, Niclas and Andriole, Gerald L. and Hoover, Robert N. and Machiela, Mitchell J. and S\orensen, Karina Dalsgaard and Borre, Michael and Blot, William J. and Zheng, Wei and Yeboah, Edward D. and Mensah, James E. and Lu, Yong-Jie and Zhang, Hong-Wei and Feng, Ninghan and Mao, Xueying and Wu, Yudong and Zhao, Shan-Chao and Sun, Zan and Thibodeau, Stephen N. and McDonnell, Shannon K. and Schaid, Daniel J. and West, Catharine M. L. and Burnet, Neil and Barnett, Gill and Maier, Christiane and Schnoeller, Thomas and Luedeke, Manuel and Kibel, Adam S. and Drake, Bettina F. and Cussenot, Olivier and Cancel-Tassin, G\'{e}raldine and Menegaux, Florence and Truong, Th\'{e}r\`{e}se and Koudou, Yves Akoli and John, Esther M. and Grindedal, Eli Marie and Maehle, Lovise and Khaw, Kay-Tee and Ingles, Sue A. and Stern, Mariana C. and Vega, Ana and G\'{o}mez-Caama\~{n}o, Antonio and Fachal, Laura and Rosenstein, Barry S. and Kerns, Sarah L. and Ostrer, Harry and Teixeira, Manuel R. and Paulo, Paula and Brand\~{a}o, Andreia and Watya, Stephen and Lubwama, Alexander and Bensen, Jeannette T. and Fontham, Elizabeth T. H. and Mohler, James and Taylor, Jack A. and Kogevinas, Manolis and Llorca, Javier and Casta\~{n}o-Vinyals, Gemma and Cannon-Albright, Lisa and Teerlink, Craig C. and Huff, Chad D. and Strom, Sara S. and Multigner, Luc and Blanchet, Pascal and Brureau, Laurent and Kaneva, Radka and Slavov, Chavdar and Mitev, Vanio and Leach, Robin J. and Weaver, Brandi and Brenner, Hermann and Cuk, Katarina and Holleczek, Bernd and Saum, Kai-Uwe and Klein, Eric A. and Hsing, Ann W. and Kittles, Rick A. and Murphy, Adam B. and Logothetis, Christopher J. and Kim, Jeri and Neuhausen, Susan L. and Steele, Linda and Ding, Yuan Chun and Isaacs, William B. and Nemesure, Barbara and Hennis, Anselm J. M. and Carpten, John and Pandha, Hardev and Michael, Agnieszka and De Ruyck, Kim and De Meerleer, Gert and Ost, Piet and Xu, Jianfeng and Razack, Azad and Lim, Jasmine and Teo, Soo-Hwang and Newcomb, Lisa F. and Lin, Daniel W. and Fowke, Jay H. and Neslund-Dudas, Christine and Rybicki, Benjamin A. and Gamulin, Marija and Lessel, Davor and Kuli\v{s}, Tomislav and Usmani, Nawaid and Singhal, Sandeep and Parliament, Matthew and Claessens, Frank and Joniau, Steven and Van den Broeck, Thomas and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Martinez, Maria Elena and Larkin, Samantha and Townsend, Paul A. and Aukim-Hastie, Claire and Bush, William S. and Aldrich, Melinda C. and Crawford, Dana C. and Srivastava, Shiv and Cullen, Jennifer C. and Petrovics, Gyorgy and Casey, Graham and Roobol, Monique J. and Jenster, Guido and van Schaik, Ron H. N. and Hu, Jennifer J. and Sanderson, Maureen and Varma, Rohit and McKean-Cowdin, Roberta and Torres, Mina and Mancuso, Nicholas and Berndt, Sonja I. and Van Den Eeden, Stephen K. and Easton, Douglas F. and Chanock, Stephen J. and Cook, Michael B. and Wiklund, Fredrik and Nakagawa, Hidewaki and Witte, John S. and Eeles, Rosalind A. and Kote-Jarai, Zsofia and Haiman, Christopher A.}, year = {2021}, pages = {65-75}, DOI = {10.1038/s41588-020-00748-0}, keywords = {prostate cancer, meta-analysis}, journal = {Nature genetics}, doi = {10.1038/s41588-020-00748-0}, volume = {53}, number = {1}, issn = {1061-4036}, title = {Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction}, keyword = {prostate cancer, meta-analysis} }

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