Naslov
Impact of the SARS-CoV-2 pandemic on the health of individuals with intoxication-type metabolic diseases-Data from the E-IMD consortium

Autori
Mütze, Ulrike ; Gleich, Florian ; Barić, Ivo ; Baumgartner, Mathias ; Burlina, Alberto ; Chapman, Kimberly A. ; Chien, Yin‐Hsiu ; Cortès‐ Saladelafont, Elisenda ; De Laet, Corinne ; Dobbelaere, Dries ; Eysken, Francois ; Gautschi, Matthias ; Santer, Rene ; Häberle, Johannes ; Joaquín, Clara ; Karall, Daniela ; Lindner, Martin ; Lund, Allan M. ; Mühlhausen, Chris ; Murphy, Elaine ; Roland, Dominique ; Ruiz Gomez, Angeles ; Skouma, Anastasia ; Grünert, Sarah C. ; Wagenmakers, Margreet ; Garbade, Sven F. ; Kölker, Stefan ; Boy, Nikolas

Izvornik
Journal of inherited metabolic disease (0141-8955) 46 (2022), 2; 220-231

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; E-IMD ; IMD ; SARS-CoV-2 ; coronavirus ; intoxication-type inherited metabolic diseases ; pandemic ; survey

Sažetak
The SARS-CoV-2 pandemic challenges healthcare systems worldwide. Within inherited metabolic disorders (IMDs) the vulnerable subgroup of intoxication-type IMDs such as organic acidurias (OA) and urea cycle disorders (UCD) show risk for infection-induced morbidity and mortality. This study (observation period February 2020 to December 2021) evaluates impact on medical health care as well as disease course and outcome of SARS-CoV-2 infections in patients with intoxication-type IMDs managed by participants of the European Registry and Network for intoxication type metabolic diseases Consortium (E-IMD). Survey's respondents managing 792 patients (n = 479 pediatric ; n = 313 adult) with intoxication- type IMDs (n = 454 OA ; n = 338 UCD) in 14 countries reported on 59 (OA: n = 36 ; UCD: n = 23), SARS-CoV-2 infections (7.4%). Medical services were increasingly requested (95%), mostly alleviated by remote technologies (86%). Problems with medical supply were scarce (5%). Regular follow-up visits were reduced in 41% (range 10%-50%). Most infected individuals (49/59 ; 83%) showed mild clinical symptoms, while 10 patients (17% ; n = 6 OA including four transplanted MMA patients ; n = 4 UCD) were hospitalized (metabolic decompensation in 30%). ICU treatment was not reported. Hospitalization rate did not differ for diagnosis or age group (p = 0.778). Survival rate was 100%. Full recovery was reported for 100% in outpatient care and 90% of hospitalized individuals. SARS-CoV-2 impacts health care of individuals with intoxication-type IMDs worldwide. Most infected individuals, however, showed mild symptoms and did not require hospitalization. SARS-CoV-2-induced metabolic decompensations were usually mild without increased risk for ICU treatment. Overall prognosis of infected individuals is very promising and IMD-specific or COVID-19-related complications have not been observed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA