Naslov
ROLE OF ARACHNOID GRANULATIONS IN CEREBROSPINAL FLUID PHYSIOLOGY: ANALYSIS BY MAGNETIC RESONANCE IMAGING

Autori
Radoš, Milan ; Živko M ; Periša A ; Orešković, Darko ; Klarica, Marijan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Pharmaca / - , 2022, 138-138

Skup
10th Croatian Congress of Pharmacology and 1st Croatian Congress of Clinical Pharmacology with international participation

Mjesto i datum
Rijeka, Opatija, Croatia, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
arachnoid granulations, : 3T magnetic resonance, dural sinuses

Sažetak
Introduction: The study aims to quantify changes in the number, size, and distribution of arachnoid granulations (AG) during the human lifespan. Material and Methods: 3T magnetic resonance imaging of the brain was performed in 120 subjects of different ages (neonate, 2 years, 10 years, 20 years, 40 years, 60 years, and 80 years) all with the normal findings of the cerebrospinal fluid system (CSF Group scanned at neonatal age was re- scanned at the age of two, while all other groups were scanned once. AG were analyzed on T2 coronal and axial sections. Results: Our study shows that 85% of neonates and 2-year-old children do not have visible AG. With age, the percentage of patients with AG in the superior sagittal sinus increases significantly, but there is no increase in the sigmoid and transverse sinuses. However, numerous individuals in different age groups do not have AG in dural sinuses. From the age of 60 onwards, AG were more numerous in the cranial bones than in the dural sinuses. Conclusions: The results show that the number, size, and distribution of AG in the superior sagittal sinus and surrounding cranial bones change significantly over a lifetime. Numerous individuals with a completely normal CSF system do not have AG in the dural sinuses, which calls into question their role in CSF physiology. It can be assumed that AG do not play an essential role in CSF absorption as it is generally accepted.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA