Naslov
DISTRIBUTION OF VARIOUS SUBSTANCES BETWEEN CSF AND INTERSTITIAL SPACE AFTER THEIR APPLICATION IN DIFFERENT CSF COMPARTMENTS

Autori
Klarica, Marijan ; Radoš, Milan ; Jurjević, Ivana ; Orešković, Darko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmaca / - , 2022, 135-135

Skup
10th Croatian Congress of Pharmacology and 1st Croatian Congress of Clinical Pharmacology with international participation

Mjesto i datum
Opatija, Croatia, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebrospinal fluid , interstitial fluid, drugs

Sažetak
Introduction: The manner of cerebrospinal fluid (CSF) movement and its influence on different substances distribution into CNS tissue have been analyzed and discussed. Methods: Investigations were done on freely moving animals. Distribution of various molecular weight substances was observed after their application into different CSF compartments. Results: Investigated substances moved freely in all directions. That included both the classically imagined circulation path from the brain ventricles into the subarachnoid space, as well as the opposite direction. The fast disappearance of organic anions (brain metabolites) from the central CSF compartment (cisterna magna), and the very low concentration of tested substances in “peripheral” CSF compartments (cortical and lumbar subarachnoid space) were observed in control conditions. When the active transport was blocked, the concentration of monitored substances in CNS tissue and in „peripheral“ CSF compartments was significantly increased. Results suggest that key role in process of substances elimination from CSF/interstitial fluid (ISF) belongs to transport mechanisms at CNS microvessels. Substance distribution was more pronounced along the interhemispheric space (intensive pulsatile movement), and significantly reduced in the temporal and parietal subarachnoid space. Conclusions: Described results imply that systolic-diastolic pulsatile movement of the CSF is responsible for the distribution of different substances through the CSF system, as well as their passage from the CSF into ISF of the CNS tissue. The brain metabolites are probably removed from CSF/ISF by means of active transport that takes place at the capillary level, which has the most important role in providing CNS homeostasis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA