Naslov
Revision of the classic concept of cerebrospinal fluid secretion by choroid plexus
(Revision of the classic concept of cerebrospinal fluid secretion by choroid plexus)

Autori
Orešković, Darko ; Vukić, Miroslav ; Maraković, Jurica ; Radoš, Milan ; Marijan Klarica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka / - , 2019, 6-6

Skup
9. hrvatski kongres farmakologije = 9th Croatian Congress of Pharmacology

Mjesto i datum
Zagreb, Hrvatska, 25.09.2019. - 28.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebrospinal fluid ; choroid plexus

Sažetak
The classic hypothesis presents the cerebrospinal fluid (CSF) as the “third circulation, ” which flows from the brain ventricles through the entire CSF system to the cortical subarachnoid space to eventually be passively absorbed into the superior sagittal sinus through arachnoid granulations. The choroid plexus represents a key organ in the classic CSF physiology and a powerful biological pump, which exclusively secretes CSF. Thereby, the CP is considered to be responsible for CSF pressure regulation and hydrocephalus development. The role of the CP in the CSF dynamics has been thoroughly analyzed by presenting arguments in favor of the thesis that the CPs are neither biological pumps nor the main site of CSF secretion ; that they do not participate in regulation of ICP/CSF pressure ; are not the reason for the existence of hydrostatic pressure gradient in the CSF system and that this gradient is not permanent (disappeared in the horizontal position) ; and that they do not generate imagined unidirectional CSF circulation, hydrocephalus development and increased ICP/CSF pressure. The classic hypothesis cannot provide an explanation for these controversies but the recently formulated Bulat-Klarica-Orešković hypothesis can. According to this hypothesis, CSF production and absorption (CSF exchange) are constant and present everywhere in the CSF system, and although the CSF is partially produced by the CP, it is mainly formed as a consequence of water filtration between the capillaries and interstitial fluid.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA