Naslov
Clinical characteristics and treatment of 255 patients hospitalised with bacterial cellulitis

Autori
Lukić, Ljiljana ; Mudrovčić, Monika ; Puljiz, Maša ; Puljiz, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
30th ECCMID 2020

Mjesto i datum
Pariz, Francuska, 18.04.2020. - 21.04.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Celluitis ; treatment

Sažetak
Background: Acute bacterial cellulitis (BC) is one of the most common skin and soft tissue infections. It places a substantial burden on the hospital system. This study assessed the clinical characteristics and treatment of BC in one healthcare center. Materials/methods: We retrospectively analyzed data of 255 patients with BC hospitalized at one university hospital center in Zagreb in 2018. The diagnosis of BC was based on clinical and laboratory features. Results: In 2018, 4, 6% of all hospitalizations in our center were due to BC. The mortality rate was 2.7% (7 patients). More than half of the patients were female (54, 9%) and the majority (74, 1%) were older than 65 (median 65, 5 years, IQR 20, 0). At admission, the majority of patients (83, 1%) were febrile (median 38, 4⁰C, IQR 1, 2) while 29, 8% appeared unwell. The most common localization was the lower extremity (83, 9%). Nearly all patients (93, 3%) had at least one risk factor. This was the first documented episode of BC for 52, 2% of the patients. Chronic ulcers were the most common entry site of infection (35, 3%), while 11, 8% of patients had no determinable entry site. Blood cultures were obtained in all patients at admission, with 4, 7% being positive. At admission, C- reactive protein was elevated in 98, 8% patients (mean 141, 7mg/L, IQR 132, 6). Leukocytosis was present in 70, 2% patients (mean 13, 5x103 cells x mm3, IQR 6, 0). The mean duration of fever after initiation of parenteral antibiotic was 3, 1 days. In 35, 3% of patients antibiotic therapy was changed. Complications arose in 23, 1% of patients. Cefazolin was the most common antibiotic initiated at admission (45, 1%), while 27, 1% patients recieved combination antimicrobial therapy. The mean duration of parenteral treatment was 10, 4 days (IQR 4, 0). Cefazolin was associated with the shortest hospital stay (mean 9, 6 days, IQR 4, 0). Conclusions: We observed a discrepancy between the relatively short time to defervescence and the relatively long duration of parenteral therapy and hospitalization. There is a potential space for shortening the length of parenteral therapy. However, the relatively high complication rate and comorbidities should be taken into mind.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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