Naslov
Defining epileptogenic networks

Autori
Šulentić, Vlatko ; Petelin Gadže, Željka ; Nanković, Sibila ; Poljaković, Zdravka ; Bujan Kovač, Andreja ; Nimac Kozina, Petra ; Đapić Ivančić, Biljana ; Krbot Skorić, Magdalena ; Mrak, Goran ; Desnica, Andrej ; Nemir, Jakob ; Marasanov, Sergej ; Radoš, Marko ; Radoš, Milan ; Ozretić, David ; Jovanović, Ivan ; Petrović, Ratimir ; Golubić, Anja Tea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neurologia Croatica. Supplement, 69 (2020), 1 / - , 2020, 36-36

Skup
7. hrvatski kongres "Dileme u neurologiji" s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 07.10.2020. - 09.10.2020

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epilepsy ; network

Sažetak
Defining epileptogenic networks is essential in the presurgical treatment of patients with pharmacoresistant epilepsy. Epileptogenic networks are defined by the brain region involved in the production and propagation of epileptic activities. The concept of epileptogenic networks is widely accepted as a more effective model of explaining the complex dynamics between epileptic seizures and epileptic anomalies within the brain. This dynamics is also a reason for discrepancies between semiology and pharmacoresistance of epilepsy, as well as epilepsy surgery failure. The process of emergence of epileptogenic networks is complex and determined by various factors. Still, a certain pattern does exist as a result of functional and anatomical connections within the brain. If semiology of seizures is clearly identifiable and well-known, it can provide useful data on epilepsy onset and spread. This is supposed to be a starting point for further treatment. After semiology has been defined, further methods for defining networks are needed. Apart from video electroencephalography (EEG) and brain magnetic resonance imaging (MRI), further diagnostics would include neuropsychological testing, brain positron emission tomography (PET) and single-photon emission computed tomography (SPECT), functional MRI, magnetoencephalography (MEG), as well as post-processing of brain MRI images with the Morphometric Analysis Program. Final confirmation of existence of epileptogenic networks is only possible by use of invasive EEG monitoring. After data have been collected by use of all of these methods, it is possible to partially define epileptogenic networks and explore options for further treatment, which is most likely to be a surgical one. Yet, expectations of the outcome may be only partially fulfilled, as epileptogenic networks are complex and very often overlapping with eloquent cortex and prone to changes during long-standing course of epilepsy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA