Pregled bibliografske jedinice broj: 1257989
Supramolecular self-assembled peptide hydrogels Ac-L-Phe-L-Phe-L-Ala-NH2 for vaccine delivery with adjuvant activity
Supramolecular self-assembled peptide hydrogels Ac-L-Phe-L-Phe-L-Ala-NH2 for vaccine delivery with adjuvant activity // Supramolecular chemistry 2022: Book of abstract / Frkanec, Leo ; Namjesnik, Danijel ; Tomišić, Vladislav (ur.).
Zagreb: Institut Ruđer Bošković, 2022. str. 40-40 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1257989 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Supramolecular self-assembled peptide hydrogels
Ac-L-Phe-L-Phe-L-Ala-NH2 for vaccine delivery with
adjuvant activity
Autori
Šišić, Marcela ; Gazdek Serdar, Nika ; Frkanec, Leo ; Frkanec, Ruža
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Supramolecular chemistry 2022: Book of abstract
/ Frkanec, Leo ; Namjesnik, Danijel ; Tomišić, Vladislav - Zagreb : Institut Ruđer Bošković, 2022, 40-40
Skup
Supramolecular chemistry 2022
Mjesto i datum
Zagreb, Hrvatska, 08.12.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Adjuvant ; peptide hydrogel ; immune reaction ; vaccine
Sažetak
Adjuvants are used in order to enhance vaccine potency by improvement of the humoral and cellmediated immune response to vaccine antigens. Adjuvants of new generation often include different biocompatible nanomaterials for sustained release of antigen and at the same time have adjuvant properties themselves. Supramolecular self-assembled peptide hydrogels have a great potential for applications in bionanotechnology and it has been shown that certain peptides possess immunostimulatory activity (1). We report here the adjuvant system based on supramolecular hydrogel of a self- assembling tripeptide Ac-L-Phe-L-Phe-L-Ala-NH2 (2) and evaluated for their in vivo adjuvant activity. The results of our experiment have shown that the examined hydrogels based on Ac-Phe-Phe-AlaNH2 and tripeptides Ac-Phe-Phe--Ala-OMe and Ac-Phe-Phe- Ala-OH induce a strong specific immune response in mice compared to the antigen itself. Also, these three adjuvant formulations modulated the type of specific immunoreaction
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-6910 - Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala (SUPeRNANO) (Frkanec, Leo, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
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