Pregled bibliografske jedinice broj: 1257639
Detection of Tahyna orthobunyavirus-neutralizing antibodies in patients with neuroinvasive disease in Croatia
Detection of Tahyna orthobunyavirus-neutralizing antibodies in patients with neuroinvasive disease in Croatia // Microorganisms, 10 (2022), 7; 1443, 12 doi:10.3390/microorganisms10071443 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1257639 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Detection of Tahyna orthobunyavirus-neutralizing antibodies in patients with neuroinvasive disease in Croatia
Autori
Vilibić-Čavlek, Tatjana ; Stevanović, Vladimir ; Savić, Vladimir ; Markelić, Domagoj ; Sabadi, Dario ; Bogdanić, Maja ; Kovač, Snježana ; Santini, Marija ; Tabain, Irena ; Potočnik-Hunjadi, Tanja ; Ferenčak, Ivana ; Škoda, Ana Marija ; Sanković, Ana ; Barbić, Ljubo
Izvornik
Microorganisms (2076-2607) 10
(2022), 7;
1443, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Croatia ; Tahyna orthobunyavirus ; neuroinvasive disease ; neutralizing antibodies
Sažetak
Background: Tahyna orthobunyavirus (TAHV) is widely distributed in continental Europe. Very few studies have analyzed TAHV seroprevalence in Croatia. We analyzed the prevalence of TAHV RNA and antibodies in Croatian patients with neuroinvasive disease (NID). Methods: A total of 218 patients with unsolved NID detected during five consecutive arbovirus transmission seasons (April 2017-October 2021) were tested. Cerebrospinal fluid (CSF) and urine samples were tested for TAHV RNA using RT-PCR. In addition, CSF and serum samples were tested for TAHV antibodies using a virus neutralization test (VNT). Results: Clinical presentations in patients with NID were meningitis (141/64.7%), meningoencephalitis (56/25.7%), myelitis (8/3.7%), and 'febrile headache' (13/5.9%). TAHV RNA was not detected in any of the tested CSF or urine samples ; however, TAHV-neutralizing (NT) antibodies were detected in 22/10.1% of patients. Detection of NT antibodies in the CSF of two patients presenting with meningitis suggested recent TAHV infection. TAHV seropositivity increased significantly with age, from 1.8% to 24.4%. There was no difference in seroprevalence between genders or areas of residence (urban, suburban/rural). The majority of seropositive patients (90.9%) resided in floodplains along the rivers in continental Croatia. Conclusions: The presented results confirm that TAHV is present in Croatia. The prevalence and clinical significance of TAHV infection in the Croatian population have yet to be determined.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Hrvatski zavod za javno zdravstvo,
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Opća bolnica Varaždin,
Medicinski fakultet, Osijek
Profili:
Vladimir Stevanović
(autor)
Tatjana Vilibić-Čavlek
(autor)
Marija Santini
(autor)
Dario Sabadi
(autor)
Ljubo Barbić
(autor)
Ivana Ferenčak
(autor)
Vladimir Savić
(autor)
Maja Bogdanić
(autor)
Irena Tabain
(autor)
Snježana Kovač
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus