Naslov
ANTIBIOTIC THERAPY IN THE COVID-19 PANDEMIC: RETROSPECTIVE COHORT STUDY OF PATIENTS HOSPITALIZED AT THE UNIVERSITY HOSPITAL OF SPLIT

Autori
Starčević, Dora ; Pranić, Shelly ; Pinjatela, Jerolima ; Skelin, Marko ; Mudnić, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Final programme and abstracts from the 10th Croatian Congress of Pharmacology and the 1st Croatian Congress of Clinical Pharmacology with International Participation / - , 2022, 224-224

Skup
10. HRVATSKI KONGRES FARMAKOLOGIJE I 1. HRVATSKI KONGRES KLINIČKE FARMAKOLOGIJE S MEĐUNARODNIM SUDJELOVANJEM

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
COVID-19, antibiotic therapy

Sažetak
INTRODUCTION: During the COVID-19 pandemic, the frequency of antibiotic use has increased globally. Our primary objective was to determine the frequency of use and type of antibiotic therapy for COVID-19 patients hospitalized at the University Hospital of Split. The secondary objective was to show the association of the use of antibiotic therapy with comorbidities, selected laboratory findings and death. SUBJECTS AND METHODS: The retrospective study is part of a larger multicenter study and was conducted on a cohort of 285 patients hospitalized at the Clinic for Infectious Diseases in Split during October and November 2020. Following variables were analysed: age, gender, number of days spent in hospital, data on previous illness, antibiotic therapy, diagnosed pneumonia, systolic and diastolic blood pressure, and laboratory findings: value of peripheral blood oxygen saturation, concentration of urea, creatinine, total bilirubin, D dimer and proportion of neutrophils and lymphocytes. RESULTS: Data on the use of antibiotic therapy refer to 266 subjects. The majority of subjects were treated with antibiotics (N=239 (84 %)). Patients on antibiotic therapy had more comorbidities compared to those non-treated (P=0.008). The antibiotic of choice was azithromycin in 141 (59%), followed by amoxicillin with clavulanic acid, used in 117 (49%) patients. Ceftriaxone was used in 51 (21%) patients, and only one patient was treated with doxycycline (0.4%). CONCLUSION: Antibiotic treatment of COVID- 19 patients requires individual clinical judgment for each patient and should be carried out in accordance with existing guidelines. In the presented cohort antibiotic therapy was not associated with a fatal outcome.

Izvorni jezik
Engleski

POVEZANOST RADA