Naslov
CBD supplementation reduces arterial blood pressure via modulation of the sympatho-chromaffin system: A substudy from the HYPER-H21-4 trial

Autori
Kumric, Marko ; Dujić, Goran ; Vrdoljak, Josip ; Svagusa, Karla ; Ticinovic Kurir, Tina ; Supe- Domic, Daniela ; Dujic, Zeljko ; Bozic, Josko

Izvornik
Biomedicine & pharmacotherapy (0753-3322) 160 (2023); 114387, 6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Catestatin ; Hypertension ; CBD

Sažetak
Data concerning the effects of cannabidiol (CBD) on blood pressure (BP) is controversial. HYPER- H21–4 was a randomized, placebo-controlled, crossover trial which sought to elucidate if 5- week administration of CBD will reduce BP in hypertensive patients. In the substudy of this trial, we aimed to establish the mechanistic back- ground of CBD-induced BP reduction. Specifically, we explored the dynamic of catestatin, a sympathoinhibitory peptide implicated in the pathophysiology of hypertension. In the present analysis, 54 patients with Grade 1 hypertension were included. 5-week administration of CBD but not placebo reduced serum catestatin concentration in comparison to baseline (13.50 [10.85–19.05] vs. 9.65 [6.37–12.26] ng/mL, p < 0.001). Serum catestatin levels at the start of the treatment period demonstrated a negative correlation with the extent of reduction in mean arterial pressure (r = (r = 0.712, p < 0.001). Overall, the results of the present study imply that the antihypertensive effects of CBD may be explained by its interaction with the sympatho- chromaffin system, although further research is warranted.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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