Naslov
Strenghts and limitations of covid saliva testing

Autori
Peroš, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
10th Croatian Congress of Pharmacology and the 1st Croatian Congress of Clinical Pharmacology with International Participation. U: Pharmaca 2022 ; 52(Suppl 2) / Mršić-Pelčić, Jasenka ; Vitezić, Dinko ; Janković, Tamara - Zagreb, 2022, 60-60

Skup
10. hrvatski kongres farmakologije ; 1. hrvatski kongres kliničke farmakologije s međunarodnim sudjelovanjem = 10th Croatian Congress of Pharmacology ; 1st Croatian Congress of Clinical Pharmacology and Therapeutics with International Participation

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
saliva ; COVID 19 ; saliva tests

Sažetak
The use of saliva as a sample material has well known advantages (easy, non-invasive, low cost, more acceptable for patients) that motivates researchers to try to develop saliva testing for current COVID-19 pandemic. Several commercial diagnostic assays for saliva COVID testing are currently available but none of these is accepted as mutually recognised test when compared to assays for nasopharyngeal specimens. The tests for samples are based on different laboratory procedures available for saliva COVID testing as well: RT-PCR testing, RTLAMP testing, rapid antigen testing, antibody testing and isolation of viable virus. Issues as sampling techniques, sampling times, population characteristics, presence and time of symptoms onset, and the height of viral load significantly affect the sensitivity of testing associated with the use of saliva samples. Lower sensitivity associated with the use of saliva samples is suggested by meta- analyses of numerous saliva testing studies. Adequate sensitivity of saliva tests to those using nasopharyngeal swabs is noticed for RT-PCR tests in case of symptomatic patients, in the sample collection during the first five days from onset of symptoms, and in case of high viral load. The accepted standard for COVID-19 testing for use with RT-PCR and rapid antigen diagnostic tests is nasopharyngeal swab. The use of saliva as an alternative sample material for rapid antigen or antibody tests is not supported although is promising. Ther is a need for further clinical studies on the saliva tests for COVID-19.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Dentalna medicina

POVEZANOST RADA