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Pregled bibliografske jedinice broj: 1254774

Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease


Knezović, Ana; Babić Perhoč, Ana; Osmanović Barilar, Jelena; Homolak, Jan; Farkaš, Vladimir; Bagarić, Robert; Grünblatt, Edna; Salković- Petrišić, Melita
Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease // 9. hrvatski kongres farmakologije : zbornik sažetaka = 9th Croatian Congress of Pharmacology : Book of abstracts
Zagreb, 2019. str. 60-61 (predavanje, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1254774 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease

Autori
Knezović, Ana ; Babić Perhoč, Ana ; Osmanović Barilar, Jelena ; Homolak, Jan ; Farkaš, Vladimir ; Bagarić, Robert ; Grünblatt, Edna ; Salković- Petrišić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9. hrvatski kongres farmakologije : zbornik sažetaka = 9th Croatian Congress of Pharmacology : Book of abstracts / - Zagreb, 2019, 60-61

Skup
9. hrvatski kongres farmakologije = 9th Croatian Congress of Pharmacology

Mjesto i datum
Zagreb, Hrvatska, 25.09.2019. - 28.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimer's disease ; transgenic mouse model ; metabolism

Sažetak
Introduction Alzheimer's disease (AD) is a neurodegenerative disorder associated with metabolic dysfunction in the brain. Our recent research demonstrated that chronic oral galactose treatment prevented/normalized early cognitive decline in a rat model of sporadic AD. Here we explored the effect of 2-month oral galactose treatment on cognition and brain metabolism in familial AD model, 5- and 9-month old transgenic Tg2576 mice. Materials and methods Cognition and behavior were tested by Morris Water Maze, Open Field and Elevated Plus Maze tests and metabolic status in plasma, cerebrospinal fluid and hippocampus was assessed by means of intraperitoneal glucose tolerance test and fluorodeoxyglucose PET scan. The level of insulin and glucagon-like peptide-1(GLP-1) was measured by ELISA. Results Oral galactose normalized alterations in cerebral glucose metabolism in both age groups of Tg2576 mice. However, while in cognitively unimpaired younger mice it additionally normalized plasma insulin and reduced grooming behavior, in older ones it caused further decrement in plasma insulin and worsening of glucose tolerance abnormalities without cognitive improvement. GLP-1 level was unaltered in all groups. Conclusions The results indicate that glucose/insulin- (not GLP-1) related metabolic changes precede cognitive impairment in Tg2576 mice model of familial AD with therapeutic potential of oral galactose seen on improvement of cerebral glucose metabolism only but not on cognition, underlying the differences in metabolic pathology between the two AD forms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
--IP-2014-09-4639 - TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI (GALAD) (Melita Šalković, Petrišić) ( CroRIS)
IP-2018-01-8938 - Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti (NutrientGLP-1) (Šalković-Petrišić, Melita, HRZZ - 2018-01) ( CroRIS)
--KK.01.1.1.01.0007 - Znanstveni centar izvrnosti - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (ZCI - NEURO) (Judaš, Miloš) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Knezović, Ana; Babić Perhoč, Ana; Osmanović Barilar, Jelena; Homolak, Jan; Farkaš, Vladimir; Bagarić, Robert; Grünblatt, Edna; Salković- Petrišić, Melita
Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease // 9. hrvatski kongres farmakologije : zbornik sažetaka = 9th Croatian Congress of Pharmacology : Book of abstracts
Zagreb, 2019. str. 60-61 (predavanje, domaća recenzija, sažetak, znanstveni)
Knezović, A., Babić Perhoč, A., Osmanović Barilar, J., Homolak, J., Farkaš, V., Bagarić, R., Grünblatt, E. & Salković- Petrišić, M. (2019) Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease. U: 9. hrvatski kongres farmakologije : zbornik sažetaka = 9th Croatian Congress of Pharmacology : Book of abstracts.
@article{article, author = {Knezovi\'{c}, Ana and Babi\'{c} Perho\v{c}, Ana and Osmanovi\'{c} Barilar, Jelena and Homolak, Jan and Farka\v{s}, Vladimir and Bagari\'{c}, Robert and Gr\"{u}nblatt, Edna and Salkovi\'{c}- Petri\v{s}i\'{c}, Melita}, year = {2019}, pages = {60-61}, keywords = {Alzheimer's disease, transgenic mouse model, metabolism}, title = {Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease}, keyword = {Alzheimer's disease, transgenic mouse model, metabolism}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {Knezovi\'{c}, Ana and Babi\'{c} Perho\v{c}, Ana and Osmanovi\'{c} Barilar, Jelena and Homolak, Jan and Farka\v{s}, Vladimir and Bagari\'{c}, Robert and Gr\"{u}nblatt, Edna and Salkovi\'{c}- Petri\v{s}i\'{c}, Melita}, year = {2019}, pages = {60-61}, keywords = {Alzheimer's disease, transgenic mouse model, metabolism}, title = {Metabolic profiling and oral galactose treatment in transgenic tg2576 mouse model of Alzheimer’s disease}, keyword = {Alzheimer's disease, transgenic mouse model, metabolism}, publisherplace = {Zagreb, Hrvatska} }




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