Naslov
The association of PNPLA3, EGF and Notch3 gene polymorphisms with alcoholic liver disease and hepatocellular carcinoma
(The association of PNPLA3, EGF and Notch3 gene olymorphisms with alcoholic liver disease and hepatocellular carcinoma)

Autori
Šisl, Dino ; Bainrauch, Ana ; Markotić, Antonio ; Ostojić, Ana ; Bralić Lang, Valerija ; Budimir Bekan, Ivan ; Krstulović Opara, Anđela ; Kelava, Tomislav ; Mrzljak, Anna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European journal of immunology, 51 (2021), Suppl 1 / - , 2021, 306-306

Skup
6th European congress of immunology (ECI 2021)

Mjesto i datum
Online, 01.09.2021. - 04.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biomarkers ; cancer immunology ; chronic inflammation and fibrosis

Sažetak
We investigated SNPs of PNPLA3, EGF and Notch3 as genetic risk factors for alcoholic liver disease (ALD) and its progression to hepatocellular carcinoma (HCC). DNA was isolated from 245 ALD patients (124 without HCC and 121 with HCC) and 70 control patients. SNPs were determined by PCR using TaqMan assays. PNPLA3 rs738409 was associated with higher risk for ALD in dominant (OR95%CI = 3.36 (1.94‐5.82) for GG/GC vs CC), recessive (OR95%CI = 3.71 (1.42‐9.69) for GG vs GC/CC) and log‐additive model (OR95%CI = 2.60 (1.69‐3.99) for G allele). This SNP was also associated with a risk for HCC in recessive (OR 95%CI = 2.72 (1.43‐ 5.17) for GG vs GC/CC) and log‐additive model (OR95%CI = 1.63 (1.14‐2.34) for G allele). EGF rs4444903 was not associated with a risk for fibrosis development. However, it was associated with a mildly increased risk for fibrosis progression to HCC in a dominant model (OR95%CI = 1.92 (1.11‐3.32), for GA/GG vs. AA). Notch3 rs1043996 was associated with lower risk for ALD in recessive model (OR95%CI = 0.32 (0.14‐ 0.72) for GG vs GA/AA). There was no association between the Notch3 genotype and risk for HCC (p>0.05). PNPLA3 rs738409 is a considerable risk factor for the ALD and its progression towards HCC, while EGF rs4444903 might be an additional risk factor for HCC development. Notch3 rs1043996 genotype is associated with a lower risk for the development of ALD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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