Naslov
Effects of trimetazidine on various physical, biochemical, and histological parameters in rats

Autori
Monika Glibić, Damir Vukoja, Luka Raos, Ivica Brizić, Ivan Merdžo, Joško Petričević

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstarct Book - 6th Global Students' Conference of Biomedical Sciences Belgrade 2019 / Ana Petronijević, Marina Markolović - Beograd : Faculty of Medicine, University of Belgrade, Belgrade, Serbia, 2019, 14-14

Skup
6th Global Students' Conference of Biomedical Sciences

Mjesto i datum
Beograd, Srbija, 17.10.2019. - 19.10.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
trimetazidine, metabolic, cardiovascular, antianginal

Sažetak
Introduction: Trimetazidine (TMZ) is an important antianginal agent that has variety of actions. It is beneficial in reducing cardiovascular risk and seems to have positive effects in patients with metabolic syndrome. Aim: Aim of this study was to investigate the metabolic and cardiovascular effects of TMZ on different physical, biochemical, and histological parameters. Material and methods: Wistar rats (n = 12) were divided into TMZ treated group and a control group. The number of male and female rats was the same in both groups as well as initial total group body weight (± 5 g). Standard food and water were given ad libitum. TMZ was administrated orally through drinking water in concentration of 10 mg/kg/day for 4 weeks. Control group was given pure drinking water only. Body weight and neck skin fold thickness were monitored throughout the study. After 4 weeks animals were sacrificed. Blood and organ samples were obtained. Levels of homocysteine, glucose, lipids, urea, and serum creatinine were measured. Heart muscle, aorta, liver, and skeletal muscle tissue were histologically evaluated. Results: TMZ group had significantly less weight gain at the end of the experiment, and smaller average neck skin fold thickness throughout the study compared to control group. Biochemical analysis showed variable homocysteine serum levels between the groups. However, blood glucose levels were significantly lower in TMZ treated animals (6.63 ± 0.83 mmol/L) compared to control group (9.86 mmol/L ± 1, 70), as well as serum levels of urea and creatinine (P < 0.05). Better lipid profile was found in the experimental group in terms of total triglycerides, total cholesterol, HDL, and LDL. Certain morphological differences were also observed in different tissues. Conclusion: These results support TMZ as a potent cardioprotective and metabolically beneficial agent. However, there are still many effects of TMZ that require further investigation for better understanding of these mechanisms

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA