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Pregled bibliografske jedinice broj: 1253747

Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface


Jurišić Dukovski, Bisera; Ljubica, Josip; Kocbek, Petra; Safundžić Kučuk, Maša; Krtalić, Iva; Hafner, Anita; Pepić, Ivan; Lovrić, Jasmina
Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface // International journal of pharmaceutics, 633 (2023), 122622; 122622, 11 doi:10.1016/j.ijpharm.2023.122622 (međunarodna recenzija, članak, znanstveni)


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Naslov
Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface

Autori
Jurišić Dukovski, Bisera ; Ljubica, Josip ; Kocbek, Petra ; Safundžić Kučuk, Maša ; Krtalić, Iva ; Hafner, Anita ; Pepić, Ivan ; Lovrić, Jasmina

Izvornik
International journal of pharmaceutics (0378-5173) 633 (2023), 122622; 122622, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
eye drops, nanoemulsion, chitosan, dilution, high shear, dynamic light scattering

Sažetak
Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and other formulation com- ponents and consequent replenishment and stabilization of the compromised tear film. Ophthalmic NEs have been on the market for over 20 years, but considering their complexity, as well as the complex nature of the ocular surface, they are still a poorly understood advanced dosage form. The objective of this study was to develop a biorelevant in vitro method that would be able to predict the behavior of ophthalmic NEs after application. With that goal, NE formulations differing in critical material attributes and critical formulation variables were employed and subjected to simulated tear turnover and blinking. By gradually increasing the complexity of the in vitro method, we were able to detect key parameters influencing NE stability. The undertaken study presents a step forward in the development of in vitro tools that are fundamental to the reliable, cost and time- effective development of innovative and generic topical ophthalmic NEs.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
IP-2019-04-2174 - Nanoemulzije unaprijeđene biofarmaceutske vrijednosti za liječenje bolesti suhoga oka (BeatDED) (Lovrić, Jasmina, HRZZ - 2019-04) ( CroRIS)
EK-EFRR-KK.01.1.1.02.0021 - Jačanje znanstveno-istraživačkih i inovacijskih kapaciteta Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu (FarmInova) (Lovrić, Jasmina, EK - Ulaganje u organizacijsku reformu i infrastrukturu u sektoru istraživanja, razvoja i inovacija) ( CroRIS)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Jurišić Dukovski, Bisera; Ljubica, Josip; Kocbek, Petra; Safundžić Kučuk, Maša; Krtalić, Iva; Hafner, Anita; Pepić, Ivan; Lovrić, Jasmina
Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface // International journal of pharmaceutics, 633 (2023), 122622; 122622, 11 doi:10.1016/j.ijpharm.2023.122622 (međunarodna recenzija, članak, znanstveni)
Jurišić Dukovski, B., Ljubica, J., Kocbek, P., Safundžić Kučuk, M., Krtalić, I., Hafner, A., Pepić, I. & Lovrić, J. (2023) Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface. International journal of pharmaceutics, 633 (122622), 122622, 11 doi:10.1016/j.ijpharm.2023.122622.
@article{article, author = {Juri\v{s}i\'{c} Dukovski, Bisera and Ljubica, Josip and Kocbek, Petra and Safund\v{z}i\'{c} Ku\v{c}uk, Ma\v{s}a and Krtali\'{c}, Iva and Hafner, Anita and Pepi\'{c}, Ivan and Lovri\'{c}, Jasmina}, year = {2023}, pages = {11}, DOI = {10.1016/j.ijpharm.2023.122622}, chapter = {122622}, keywords = {eye drops, nanoemulsion, chitosan, dilution, high shear, dynamic light scattering}, journal = {International journal of pharmaceutics}, doi = {10.1016/j.ijpharm.2023.122622}, volume = {633}, number = {122622}, issn = {0378-5173}, title = {Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface}, keyword = {eye drops, nanoemulsion, chitosan, dilution, high shear, dynamic light scattering}, chapternumber = {122622} }
@article{article, author = {Juri\v{s}i\'{c} Dukovski, Bisera and Ljubica, Josip and Kocbek, Petra and Safund\v{z}i\'{c} Ku\v{c}uk, Ma\v{s}a and Krtali\'{c}, Iva and Hafner, Anita and Pepi\'{c}, Ivan and Lovri\'{c}, Jasmina}, year = {2023}, pages = {11}, DOI = {10.1016/j.ijpharm.2023.122622}, chapter = {122622}, keywords = {eye drops, nanoemulsion, chitosan, dilution, high shear, dynamic light scattering}, journal = {International journal of pharmaceutics}, doi = {10.1016/j.ijpharm.2023.122622}, volume = {633}, number = {122622}, issn = {0378-5173}, title = {Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface}, keyword = {eye drops, nanoemulsion, chitosan, dilution, high shear, dynamic light scattering}, chapternumber = {122622} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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