Pregled bibliografske jedinice broj: 1253222
Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell Death
Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell Death // Cancers, 15 (2023), 3; 15030981, 20 doi:10.3390/cancers15030981 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1253222 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell Death
Autori
Glumac, Mateo ; Čikeš Čulić, Vedrana ; Marinović-Terzić, Ivana ; Radan, Mila
Izvornik
Cancers (2072-6694) 15
(2023), 3;
15030981, 20
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
nerolidol ; sesquiterpenes ; cell death pathways ; calcium signaling ; ER stress
Sažetak
Nerolidol is a naturally occurring sesquiterpene alcohol with multiple properties, including antioxidant, antibacterial, and antiparasitic activities. A few studies investigating the antitumor properties of nerolidol have shown positive results in both cell culture and mouse models. In this study, we investigated the antitumor mechanism of cis-nerolidol in bladder carcinoma cell lines. The results of our experiments on two bladder carcinoma cell lines revealed that nerolidol inhibited cell proliferation and induced two distinct cell death pathways. We confirmed that cis-nerolidol induces DNA damage and ER stress. A mechanistic study identified a common cAMP, Ca2+, and MAPK axis involved in signal propagation and amplification, leading to ER stress. Inhibition of any part of this signaling cascade prevented both cell death pathways. The two cell death mechanisms can be distinguished by the involvement of caspases. The early occurring cell death pathway is characterized by membrane blebbing and cell swelling followed by membrane rupture, which can be prevented by the inhibition of caspase activation. In the late cell death pathway, which was found to be caspase-independent, cytoplasmic vacuolization and changes in cell shape were observed. cis-Nerolidol shows promising antitumor activity through an unorthodox mechanism of action that could help target resistant forms of malignancies, such as bladder cancer.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Farmacija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-6897 - Istraživanje bioaktivnih spojeva iz dalmatinskog bilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravlje (BioActCom) (Miloš, Mladen, HRZZ - 2014-09) ( CroRIS)
HRZZ-IP-2016-06-3097 - Uloga proteina Spartan u DNA replikaciji (SprtnRep) (Marinović Terzić, Ivana, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Kemijsko-tehnološki fakultet, Split,
Medicinski fakultet, Split
Profili:
Mila Radan
(autor)
Ivana Marinović Terzić
(autor)
Vedrana Čikeš Čulić
(autor)
Mateo Glumac
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus