Pregled bibliografske jedinice broj: 1253172
Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type- 1 Diabetes
Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type- 1 Diabetes // Nutrients, 15 (2023), 3; 600, 20 doi:10.3390/nu15030600 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1253172 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Relationship of Glucose, C-peptide, Leptin, and
BDNF in Maternal and Umbilical Vein Blood in Type-
1 Diabetes
Autori
Josip Đelmiš, Slavko Oreškovic, Vesna Elveđi Gašparović, Mirta Starčevic, Mislav Herman, Nada Dessardo, Vito Starčevic, Marina Ivanišević
Izvornik
Nutrients (2072-6643) 15
(2023), 3;
600, 20
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
BDNF ; CRP ; C-peptide ; leptin ; pregnancy ; skinfold thickness ; thyroid hormones ; type-1 diabetes mellitus
Sažetak
Abstract The study aimed to determine the relationship between glucose, C-peptide, brain- derived neurotrophic factor (BDNF), and leptin between mother and fetus and neonatal weight. Methods: In the prospective observational cohort study, we included 66 women with type-1 diabetes mellitus (T1DM). According to the z-score for neonatal weight, patients were divided into healthy-weight neonates (n = 42) and overweight neonates (n = 24). The maternal blood samples were taken during pregnancy and cesarean section when the umbilical vein blood sample was also withdrawn. The maternal vein sera were analyzed for fasting glucose, C- reactive protein (CRP), leptin, BDNF, TSH, FT3, and FT4. The umbilical vein sera were analyzed for glucose, C-peptide, leptin, TSH, thyroid- stimulating protein (FT3), free thyroxine (FT4), and BDNF concentration. The neonatologist measured the skinfold thickness on the third day of neonatal life. Results: A strong correlation was confirmed between maternal and umbilical vein glucose concentration and maternal glucose and C- peptide in umbilical vein blood. A negative correlation was found between the concentration of BDNF in the umbilical vein and glucose in maternal blood. A strong correlation was seen between BMI and maternal blood leptin concentration, neonatal fat body mass, and umbilical vein blood leptin concentration. Higher BMI elevated BDNF, and TSH increase the odds for overweight neonates in the first trimester of pregnancy. Maternal higher leptin concentration in the first trimester decrease the odds of overweight neonates. Conclusions: Maternal glucose concentrations affect the fetus’s glucose, C- peptide, and BDNF concentrations. Leptin levels increase in maternal blood due to increased body mass index, and in the neonate, fat body mass is responsible for increased leptin concentrations.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Nutricionizam, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Slavko Orešković
(autor)
Marina Ivanišević
(autor)
Vesna Elveđi-Gašparović
(autor)
Josip Đelmiš
(autor)
Vito Starčević
(autor)
Mirta Starčević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE