Naslov
Association of subclinical myocardial deformation and disease activity in psoriatic arthritis

Autori
Pletikosić, Ivan ; Marasović Krstulović, Daniela ; Sušilović Grabovac, Zora ; Duplančić, Darko ; Perković, Dijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
ANNALS OF THE RHEUMATIC DISEASES / - : BMJ, 2019, 1276-1277

Skup
Annual European Congress of Rheumatology (EULAR 2019)

Mjesto i datum
Madrid, Španjolska, 12.06.2019. - 15.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PSORIATIC ARTHRITIS ; MYOCARDIAL DEFORMATION

Sažetak
Background: Subclinical impaired myocardial deformation is common in patients with PsA, even with no clinical evidence for CV disease (1). Recent evidence supports the link between the extent of inflammation and CV risk in patients with PsA (2). Elevated levels of inflammatory biomarkers and high activity of joint inflammation were associated with a higher burden of atherosclerosis (2). It is suggested that patients with active disease may have an impaired myocardial deformation (3). But it is unclear if the patients with higher activity of PsA have higher grade of myocardial impairment than the patients without activity of inflammatory rheumatic disease. Speckle-tracking echocardiography (STE), an angle-independent technique, was proposed as a reliable and sensitive method for assessment of subclinical myocardial dysfunction (4). Objectives: The aim of the study was to assess if there is an association of disease activity of PsA assessed by DAPSA with grade od myocardial impairment measured by Speckle-tracking echocardiography (STE). Methods: 48 PsA patients (28 females, 20 males) who fulfilled Caspar criteria, with no clinically evident CV disease or concomitant diseases, were included in the study. Patients who had classic CV risk factors or had experienced CV or cerebrovascular events were excluded. Upon clinical and laboratory evaluation, all subjects underwent conventional echocardiography and 2- dimensional speckle tracking echocardiography (STE). Results: The results of STE analysis showed that patients with higher DAPSA result have average global longitudinal strain AM ± SD -19.44 ± 2.98%. Significant correlation was determined between PsA patients with higher DAPSA result and lower values of the variable GLS (R=0, 368 ; p=0.0036). Conclusion: Subclinical impaired myocardial deformation measured by STE was more common in PsA patients with higher disease activity, even in absence of traditional CV risk factors. Global longitudinal strain was associated with the status of PsA disease activity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA