Pregled bibliografske jedinice broj: 1252796
Mesenchymal stromal cells: potential option for COVID-19 treatment
Mesenchymal stromal cells: potential option for COVID-19 treatment // Pharmaceutics, 13 (2021), 9; 1481, 14 doi:10.3390/pharmaceutics13091481 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1252796 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mesenchymal stromal cells: potential option for COVID-19 treatment
(Mesenchymal stromal cells: potential option for
COVID-19 treatment)
Autori
Primorac, Dragan ; Čemerin, Martin ; Matišić, Vid ; Molnar, Vilim ; Strbad, Marko ; Girandon, Lenart ; Zenić, Lucija ; Knežević, Miomir ; Minger, Stephen ; Polančec, Denis
Izvornik
Pharmaceutics (1999-4923) 13
(2021), 9;
1481, 14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
COVID-19 ; mesenchymal stromal cells ; MSCs ; immunomodulation ; ARDS
Sažetak
The COVID-19 pandemic has significantly impacted the way of life worldwide and continues to bring high mortality rates to at-risk groups. Patients who develop severe COVID-19 pneumonia, often complicated with ARDS, are left with limited treatment options with no targeted therapy currently available. One of the features of COVID- 19 is an overaggressive immune reaction that leads to multiorgan failure. Mesenchymal stromal cell (MSC) treatment has been in development for various clinical indications for over a decade, with a safe side effect profile and promising results in preclinical and clinical trials. Therefore, the use of MSCs in COVID-19-induced respiratory failure and ARDS was a logical step in order to find a potential treatment option for the most severe patients. In this review, the main characteristics of MSCs, their proposed mechanism of action in COVID-19 treatment and the effect of this therapy in published case reports and clinical trials are discussed.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
Dječja bolnica Srebrnjak,
Specijalna bolnica Sv. Katarina,
Fakultet za dentalnu medicinu i zdravstvo, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE