Pregled bibliografske jedinice broj: 1252443
Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data
Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data // Life, 13 (2023), 1; 152, 14 doi:10.3390/life13010152 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1252443 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data
Autori
Krišto, Mirela ; Lugović-Mihić, Liborija ; Muñoz, Melba ; Rupnik, Maja ; Mahnic, Aleksander ; Ozretić, Petar ; Jaganjac, Morana ; Ćesić, Diana ; Kuna, Matea
Izvornik
Life (2075-1729) 13
(2023), 1;
152, 14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
gut microbiome ; intestinal microbiome composition ; chronic spontaneous urticaria ; dysbiosis ; metabolome
Sažetak
Recent studies have linked gut microorganism composition and chronic urticaria (CU) ; however, the underlying mechanisms responsible for this connection are unknown. Since the human immune system is in homeostasis with microbiota, and the composition of the microbiome regulates the development and function of the immune system, it is likely that an alteration of microbiota components (a dysbiosis) could influence the course of chronic spontaneous urticaria (CSU), including disease severity, patient quality of life and treatment outcome. To date, several studies have identified changes in the gut microbiota composition of patients with CSU, though only a few have exhibited metabolic abnormalities associated with gut dysbiosis. The studies on CSU patients predominantly showed that the relative abundance of beneficial bacteria was decreased (Firmicutes and Bacteroides), while that of opportunistic bacteria was increased (Enterobacteria and Proteobacteria). In addition, serum metabolome analysis revealed that gut microbiota-associated alterations in unsaturated fatty acids and the butanoate metabolism pathway may play a role in CSU. These findings are potentially associated with inflammation mediated by the imbalance of Th1/Th2/Th17 cytokines, which might contribute to CSU pathogenesis. Further research in this field could improve clinical, diagnostic, and therapeutic approaches to patients with CSU. By applying new knowledge on gut microbial communities and metabolomics, future CSU therapies could modify the microbiota composition using agents such as probiotics or other similar agents, which, in combination with current standard therapies, could hopefully lead to a reduction in symptoms and an improved quality of life for CSU patients.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
NadSve-Sveučilište u Zagrebu-Lugović-2021 - Povezanost obilježja mikrobioma, psihičkog stresa i upale kože (Lugović Mihić, Liborija, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Lugović-2020 - Obilježja mikrobioma i kvalitete života bolesnika s kroničnom urtikarijom (Lugović Mihić, Liborija, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Lugović-2019 - Obilježja mikrobioma i kvalitete života bolesnika s kroničnom urtikarijom (Lugović Mihić, Liborija, NadSve ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Matea Kuna
(autor)
Liborija Lugović Mihić
(autor)
Petar Ozretić
(autor)
Morana Jaganjac
(autor)
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.mdpi.com www.mdpi.com fulir.irb.hrCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus