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Pregled bibliografske jedinice broj: 1252277

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

(Understanding Society Scientific Group) Shrine, Nick; Understanding Society Scientific Group; Guyatt, Anna L.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Hobbs, Brian D.; Melbourne, Carl A.; Batini, Chiara; Fawcett, Katherine A.; Song, Kijoung et al.
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries // Nature Genetics, 51 (2019), 3; 481-493 doi:10.1038/s41588-018-0321-7 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1252277 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Autori
Shrine, Nick ; Understanding Society Scientific Group ; Guyatt, Anna L. ; Erzurumluoglu, A. Mesut ; Jackson, Victoria E. ; Hobbs, Brian D. ; Melbourne, Carl A. ; Batini, Chiara ; Fawcett, Katherine A. ; Song, Kijoung ; Sakornsakolpat, Phuwanat ; Li, Xingnan ; Boxall, Ruth ; Reeve, Nicola F. ; Obeidat, Ma’en ; Zhao, Jing Hua ; Wielscher, Matthias ; Weiss, Stefan ; Kentistou, Katherine A. ; Cook, James P. ; Sun, Benjamin B. ; Zhou, Jian ; Hui, Jennie ; Karrasch, Stefan ; Imboden, Medea ; Harris, Sarah E ; Marten, Jonathan ; Enroth, Stefan ; Kerr, Shona M. ; Surakka, Ida ; Vitart, Veronique ; Lehtimäki, Terho ; Allen, Richard J. ; Bakke, Per S. ; Beaty, Terri H. ; Bleecker, Eugene R. ; Bossé, Yohan ; Brandsma, Corry-Anke ; Chen, Zhengming ; Crapo, James D. ; Danesh, John ; DeMeo, Dawn L. ; Dudbridge, Frank ; Ewert, Ralf ; Gieger, Christian ; Gulsvik, Amund ; Hansell, Anna L. ; Hao, Ke ; Hoffman, Joshua D. ; Hokanson, John E. ; Homuth, Georg ; Joshi, Peter K. ; Joubert, Philippe ; Langenberg, Claudia ; Li, Xuan ; Li, Liming ; Lin, Kuang ; Lind, Lars ; Locantore, Nicholas ; Luan, Jian’an ; Mahajan, Anubha ; Maranville, Joseph C. ; Murray, Alison ; Nickle, David C. ; Packer, Richard ; Parker, Margaret M. ; Paynton, Megan L. ; Porteous, David J. ; Prokopenko, Dmitry ; Qiao, Dandi ; Rawal, Rajesh ; Runz, Heiko ; Sayers, Ian ; Sin, Don D ; Smith, Blair H ; Soler Artigas, María ; Sparrow, David ; Tal-Singer, Ruth ; Timmers, Paul R. H. J. ; Van den Berge, Maarten ; Whittaker, John C. ; Woodruff, Prescott G. ; Yerges-Armstrong, Laura M. ; Troyanskaya, Olga G. ; Raitakari, Olli T. ; Kähönen, Mika ; Polašek, Ozren ; Gyllensten, Ulf ; Rudan, Igor ; Deary, Ian J. ; Probst-Hensch, Nicole M. ; Schulz, Holger ; James, Alan L ; Wilson, James F. ; Stubbe, Beate ; Zeggini, Eleftheria ; Jarvelin, Marjo-Riitta ; Wareham, Nick ; Silverman, Edwin K. ; Hayward, Caroline ; Morris, Andrew P. ; Butterworth, Adam S. ; Scott, Robert A. ; Walters, Robin G. ; Meyers, Deborah A. ; Cho, Michael H. ; Strachan, David P. ; Hall, Ian P. ; Tobin, Martin D. ; Wain, Louise V.

Kolaboracija
Understanding Society Scientific Group

Izvornik
Nature Genetics (1061-4036) 51 (2019), 3; 481-493

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GENOME-WIDE ASSOCIATION ; LOCI ; GWAS ; HERITABILITY ; VARIANTS ; COPD

Sažetak
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400, 102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

(Understanding Society Scientific Group) Shrine, Nick; Understanding Society Scientific Group; Guyatt, Anna L.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Hobbs, Brian D.; Melbourne, Carl A.; Batini, Chiara; Fawcett, Katherine A.; Song, Kijoung et al.
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries // Nature Genetics, 51 (2019), 3; 481-493 doi:10.1038/s41588-018-0321-7 (međunarodna recenzija, članak, znanstveni)
(Understanding Society Scientific Group) (Understanding Society Scientific Group) Shrine, N., Understanding Society Scientific Group, Guyatt, A., Erzurumluoglu, A., Jackson, V., Hobbs, B., Melbourne, C., Batini, C., Fawcett, K. & Song, K. (2019) New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, 51 (3), 481-493 doi:10.1038/s41588-018-0321-7.
@article{article, author = {Shrine, Nick and Guyatt, Anna L. and Erzurumluoglu, A. Mesut and Jackson, Victoria E. and Hobbs, Brian D. and Melbourne, Carl A. and Batini, Chiara and Fawcett, Katherine A. and Song, Kijoung and Sakornsakolpat, Phuwanat and Li, Xingnan and Boxall, Ruth and Reeve, Nicola F. and Obeidat, Ma’en and Zhao, Jing Hua and Wielscher, Matthias and Weiss, Stefan and Kentistou, Katherine A. and Cook, James P. and Sun, Benjamin B. and Zhou, Jian and Hui, Jennie and Karrasch, Stefan and Imboden, Medea and Harris, Sarah E and Marten, Jonathan and Enroth, Stefan and Kerr, Shona M. and Surakka, Ida and Vitart, Veronique and Lehtim\"{a}ki, Terho and Allen, Richard J. and Bakke, Per S. and Beaty, Terri H. and Bleecker, Eugene R. and Boss\'{e}, Yohan and Brandsma, Corry-Anke and Chen, Zhengming and Crapo, James D. and Danesh, John and DeMeo, Dawn L. and Dudbridge, Frank and Ewert, Ralf and Gieger, Christian and Gulsvik, Amund and Hansell, Anna L. and Hao, Ke and Hoffman, Joshua D. and Hokanson, John E. and Homuth, Georg and Joshi, Peter K. and Joubert, Philippe and Langenberg, Claudia and Li, Xuan and Li, Liming and Lin, Kuang and Lind, Lars and Locantore, Nicholas and Luan, Jian’an and Mahajan, Anubha and Maranville, Joseph C. and Murray, Alison and Nickle, David C. and Packer, Richard and Parker, Margaret M. and Paynton, Megan L. and Porteous, David J. and Prokopenko, Dmitry and Qiao, Dandi and Rawal, Rajesh and Runz, Heiko and Sayers, Ian and Sin, Don D and Smith, Blair H and Soler Artigas, Mar\'{\i}a and Sparrow, David and Tal-Singer, Ruth and Timmers, Paul R. H. J. and Van den Berge, Maarten and Whittaker, John C. and Woodruff, Prescott G. and Yerges-Armstrong, Laura M. and Troyanskaya, Olga G. and Raitakari, Olli T. and K\"{a}h\"{o}nen, Mika and Pola\v{s}ek, Ozren and Gyllensten, Ulf and Rudan, Igor and Deary, Ian J. and Probst-Hensch, Nicole M. and Schulz, Holger and James, Alan L and Wilson, James F. and Stubbe, Beate and Zeggini, Eleftheria and Jarvelin, Marjo-Riitta and Wareham, Nick and Silverman, Edwin K. and Hayward, Caroline and Morris, Andrew P. and Butterworth, Adam S. and Scott, Robert A. and Walters, Robin G. and Meyers, Deborah A. and Cho, Michael H. and Strachan, David P. and Hall, Ian P. and Tobin, Martin D. and Wain, Louise V.}, year = {2019}, pages = {481-493}, DOI = {10.1038/s41588-018-0321-7}, keywords = {GENOME-WIDE ASSOCIATION, LOCI, GWAS, HERITABILITY, VARIANTS, COPD}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0321-7}, volume = {51}, number = {3}, issn = {1061-4036}, title = {New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries}, keyword = {GENOME-WIDE ASSOCIATION, LOCI, GWAS, HERITABILITY, VARIANTS, COPD} }
@article{article, author = {Shrine, Nick and Guyatt, Anna L. and Erzurumluoglu, A. Mesut and Jackson, Victoria E. and Hobbs, Brian D. and Melbourne, Carl A. and Batini, Chiara and Fawcett, Katherine A. and Song, Kijoung and Sakornsakolpat, Phuwanat and Li, Xingnan and Boxall, Ruth and Reeve, Nicola F. and Obeidat, Ma’en and Zhao, Jing Hua and Wielscher, Matthias and Weiss, Stefan and Kentistou, Katherine A. and Cook, James P. and Sun, Benjamin B. and Zhou, Jian and Hui, Jennie and Karrasch, Stefan and Imboden, Medea and Harris, Sarah E and Marten, Jonathan and Enroth, Stefan and Kerr, Shona M. and Surakka, Ida and Vitart, Veronique and Lehtim\"{a}ki, Terho and Allen, Richard J. and Bakke, Per S. and Beaty, Terri H. and Bleecker, Eugene R. and Boss\'{e}, Yohan and Brandsma, Corry-Anke and Chen, Zhengming and Crapo, James D. and Danesh, John and DeMeo, Dawn L. and Dudbridge, Frank and Ewert, Ralf and Gieger, Christian and Gulsvik, Amund and Hansell, Anna L. and Hao, Ke and Hoffman, Joshua D. and Hokanson, John E. and Homuth, Georg and Joshi, Peter K. and Joubert, Philippe and Langenberg, Claudia and Li, Xuan and Li, Liming and Lin, Kuang and Lind, Lars and Locantore, Nicholas and Luan, Jian’an and Mahajan, Anubha and Maranville, Joseph C. and Murray, Alison and Nickle, David C. and Packer, Richard and Parker, Margaret M. and Paynton, Megan L. and Porteous, David J. and Prokopenko, Dmitry and Qiao, Dandi and Rawal, Rajesh and Runz, Heiko and Sayers, Ian and Sin, Don D and Smith, Blair H and Soler Artigas, Mar\'{\i}a and Sparrow, David and Tal-Singer, Ruth and Timmers, Paul R. H. J. and Van den Berge, Maarten and Whittaker, John C. and Woodruff, Prescott G. and Yerges-Armstrong, Laura M. and Troyanskaya, Olga G. and Raitakari, Olli T. and K\"{a}h\"{o}nen, Mika and Pola\v{s}ek, Ozren and Gyllensten, Ulf and Rudan, Igor and Deary, Ian J. and Probst-Hensch, Nicole M. and Schulz, Holger and James, Alan L and Wilson, James F. and Stubbe, Beate and Zeggini, Eleftheria and Jarvelin, Marjo-Riitta and Wareham, Nick and Silverman, Edwin K. and Hayward, Caroline and Morris, Andrew P. and Butterworth, Adam S. and Scott, Robert A. and Walters, Robin G. and Meyers, Deborah A. and Cho, Michael H. and Strachan, David P. and Hall, Ian P. and Tobin, Martin D. and Wain, Louise V.}, year = {2019}, pages = {481-493}, DOI = {10.1038/s41588-018-0321-7}, keywords = {GENOME-WIDE ASSOCIATION, LOCI, GWAS, HERITABILITY, VARIANTS, COPD}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0321-7}, volume = {51}, number = {3}, issn = {1061-4036}, title = {New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries}, keyword = {GENOME-WIDE ASSOCIATION, LOCI, GWAS, HERITABILITY, VARIANTS, COPD} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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