Naslov
Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications

Autori
Ogresta, Doris ; Mrzljak, Anna ; Cigrovski Berković, Maja ; Bilić-Ćurčić, Ines ; Stojsavljevic-Shapeski, Sanja ; Virovic-Jukic, Lucija

Izvornik
Journal of clinical and translational hepatology (2225-0719) 10 (2022), 2; 339-355

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Coagulation ; Endothelial dysfunction ; Insulin resistance ; Non-alcoholic fatty liver disease ; Non-alcoholic steatohepatitis ; Platelet dysfunction ; Thrombosis

Sažetak
Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation system. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. Through a review of the literature, we consider and discuss possible disorders in the coagulation cascade and fibrinolysis, endothelial dysfunction and platelet abnormalities in patients with NAFLD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA