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Pregled bibliografske jedinice broj: 1251963

Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis

(Paediatric Rheumatology International Trials Organisation (PRINTO) ; UK CAPS study ; German ICON study) van Straalen, Joeri W.; Kearsley‐Fleet, Lianne; Klotsche, Jens; de Roock, Sytze; Minden, Kirsten; Heiligenhaus, Arnd; Hyrich, Kimme L.; de Boer, Joke H.; Lamot, Lovro; Olivieri, Alma N. et al.
Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis // Arthritis & Rheumatology, 75 (2022), 2; 318-327 doi:10.1002/art.42329 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1251963 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis

Autori
Van Straalen, Joeri W. ; Kearsley‐Fleet, Lianne ; Klotsche, Jens ; de Roock, Sytze ; Minden, Kirsten ; Heiligenhaus, Arnd ; Hyrich, Kimme L. ; de Boer, Joke H. ; Lamot, Lovro ; Olivieri, Alma N. ; Gallizzi, Romina ; Smolewska, Elzbieta ; Faugier, Enrique ; Pastore, Serena ; Hashkes, Philip J. ; Herrera, Cristina N. ; Emminger, Wolfgang ; Consolini, Rita ; Wulffraat, Nico M. ; Ruperto, Nicolino ; Swart, Joost F.

Kolaboracija
Paediatric Rheumatology International Trials Organisation (PRINTO) ; UK CAPS study ; German ICON study

Izvornik
Arthritis & Rheumatology (2326-5191) 75 (2022), 2; 318-327

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Uveitis, Juvenile Idiopathic Arthritis, JIA

Sažetak
Objective: To develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA) for clinical application. Methods: Data from the international Pharmachild registry were used to develop a multivariable Cox proportional hazards model. Predictors were selected by backward selection, and missing values were handled by multiple imputation. The model was subsequently validated and recalibrated in 2 inception cohorts: the UK Childhood Arthritis Prospective Study (CAPS) study and the German Inception Cohort of Newly diagnosed patients with juvenile idiopathic arthritis (ICON) study. Model performance was evaluated by calibration plots and C statistics for the 2-, 4-, and 7-year risk of uveitis. A diagram and digital risk calculator were created for use in clinical practice. Results: A total of 5, 393 patients were included for model development, and predictor variables were age at JIA onset (hazard ratio [HR] 0.83 [95% confidence interval (95% CI) 0.77-0.89]), ANA positivity (HR 1.59 [95% CI 1.06-2.38]), and International League of Associations for Rheumatology category of JIA (HR for oligoarthritis, psoriatic arthritis, and undifferentiated arthritis versus rheumatoid factor-negative polyarthritis 1.40 [95% CI 0.91- 2.16]). Performance of the recalibrated prediction model in the validation cohorts was acceptable ; calibration plots indicated good calibration and C statistics for the 7-year risk of uveitis (0.75 [95% CI 0.72-0.79] for the ICON cohort and 0.70 [95% CI 0.64-0.76] for the CAPS cohort). Conclusion: We present for the first time a validated prognostic tool for easily predicting chronic uveitis risk for individual JIA patients using common clinical parameters. This model could be used by clinicians to inform patients/parents and provide guidance in choice of uveitis screening frequency and arthritis drug therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Lovro Lamot (autor)

Poveznice na cjeloviti tekst rada:

doi pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

(Paediatric Rheumatology International Trials Organisation (PRINTO) ; UK CAPS study ; German ICON study) van Straalen, Joeri W.; Kearsley‐Fleet, Lianne; Klotsche, Jens; de Roock, Sytze; Minden, Kirsten; Heiligenhaus, Arnd; Hyrich, Kimme L.; de Boer, Joke H.; Lamot, Lovro; Olivieri, Alma N. et al.
Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis // Arthritis & Rheumatology, 75 (2022), 2; 318-327 doi:10.1002/art.42329 (međunarodna recenzija, članak, znanstveni)
(Paediatric Rheumatology International Trials Organisation (PRINTO) ; UK CAPS study ; German ICON study) (Paediatric Rheumatology International Trials Organisation (PRINTO), UK CAPS study, German ICON study) van Straalen, J., Kearsley‐Fleet, L., Klotsche, J., de Roock, S., Minden, K., Heiligenhaus, A., Hyrich, K., de Boer, J., Lamot, L. & Olivieri, A. (2022) Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis. Arthritis & Rheumatology, 75 (2), 318-327 doi:10.1002/art.42329.
@article{article, author = {van Straalen, Joeri W. and Kearsley‐Fleet, Lianne and Klotsche, Jens and de Roock, Sytze and Minden, Kirsten and Heiligenhaus, Arnd and Hyrich, Kimme L. and de Boer, Joke H. and Lamot, Lovro and Olivieri, Alma N. and Gallizzi, Romina and Smolewska, Elzbieta and Faugier, Enrique and Pastore, Serena and Hashkes, Philip J. and Herrera, Cristina N. and Emminger, Wolfgang and Consolini, Rita and Wulffraat, Nico M. and Ruperto, Nicolino and Swart, Joost F.}, year = {2022}, pages = {318-327}, DOI = {10.1002/art.42329}, keywords = {Uveitis, Juvenile Idiopathic Arthritis, JIA}, journal = {Arthritis and Rheumatology}, doi = {10.1002/art.42329}, volume = {75}, number = {2}, issn = {2326-5191}, title = {Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis}, keyword = {Uveitis, Juvenile Idiopathic Arthritis, JIA} }
@article{article, author = {van Straalen, Joeri W. and Kearsley‐Fleet, Lianne and Klotsche, Jens and de Roock, Sytze and Minden, Kirsten and Heiligenhaus, Arnd and Hyrich, Kimme L. and de Boer, Joke H. and Lamot, Lovro and Olivieri, Alma N. and Gallizzi, Romina and Smolewska, Elzbieta and Faugier, Enrique and Pastore, Serena and Hashkes, Philip J. and Herrera, Cristina N. and Emminger, Wolfgang and Consolini, Rita and Wulffraat, Nico M. and Ruperto, Nicolino and Swart, Joost F.}, year = {2022}, pages = {318-327}, DOI = {10.1002/art.42329}, keywords = {Uveitis, Juvenile Idiopathic Arthritis, JIA}, journal = {Arthritis and Rheumatology}, doi = {10.1002/art.42329}, volume = {75}, number = {2}, issn = {2326-5191}, title = {Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis}, keyword = {Uveitis, Juvenile Idiopathic Arthritis, JIA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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