Naslov
Antiproliferative and antibacterial activity in vitro of amidino substituted 2-naphthylbenzazoles

Autori
Racané, Livio ; Ptiček, Lucija ; Hranjec, Marijana ; Persoons, Leentije ; Dealmans, Dirk ; Banjanac, Mihailo ; Radovanović, Vedrana

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Book of proceedings: international scientific conference / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska / Malinović, Borislav - Banja Luka : University in Banjaluka, Faculty of Technology, 2023, 33-41

ISBN
978-99938-54-98-2

Skup
XIV Conference of chemists, technologists and environmentalists of Republic of Srpska

Mjesto i datum
Banja Luka, Bosna i Hercegovina, 21.10.2022. - 22.10.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
amidines, antibacterial activity, antiproliferative activity, benzimidazoles, benzothiazoles

Sažetak
Taking into account that benzimidazole, benzothiazole and benzoxazole nuclei, as a part of nitrogen heterocycles, are highly-privileged building structural motifs in organic and medicinal chemistry, they played unavoidable role in the rational drug design. Among their versatile pharmacological features, the most important ones are antimicrobial, antitumor, antiviral, anti- inflammanory, antihistaminic, antioxidant, etc. On the other hand, amidines are known as important pharmacophore functional groups usually placed at the termini of the biologically active molecules. They are a structural parts of the numerous biologically active compounds and many important medical and biochemical agents. Amidine groups, usually in cationic form, could significantly contribute to the molecule/possible biological target complex stability. Herein we present the synthesis, structural characterization and biological evaluation of amidino substituted benzimidazole and benzothiazole derivatives substituted with 2- naphthyl ring. All targeted compounds have been synthesized according to the conventional methods of organic synthesis. They have been evaluated on the several human cancer cell lines for their antiproliferative activity in vitro. Additionally, all synthesized compounds have been tested against several Gram negative and Gram positive bacterial strains in vitro.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA