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Pregled bibliografske jedinice broj: 1251218

Genome-wide association study identifies 48 common genetic variants associated with handedness

Cuellar-Partida, Gabriel; Tung, Joyce Y.; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole A.; Barroso, Inês; Beckmann, Jacques S.; Boks, Marco P.; Boomsma, Dorret I. et al.
Genome-wide association study identifies 48 common genetic variants associated with handedness // Nature Human Behaviour, 5 (2020), 1; 59-70 doi:10.1038/s41562-020-00956-y (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1251218 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide association study identifies 48 common genetic variants associated with handedness

Autori
Cuellar-Partida, Gabriel ; Tung, Joyce Y. ; Eriksson, Nicholas ; Albrecht, Eva ; Aliev, Fazil ; Andreassen, Ole A. ; Barroso, Inês ; Beckmann, Jacques S. ; Boks, Marco P. ; Boomsma, Dorret I. ; Boyd, Heather A. ; Breteler, Monique M. B. ; Campbell, Harry ; Chasman, Daniel I. ; Cherkas, Lynn F. ; Davies, Gail ; de Geus, Eco J. C. ; Deary, Ian J. ; Deloukas, Panos ; Dick, Danielle M. ; Duffy, David L. ; Eriksson, Johan G. ; Esko, Tõnu ; Feenstra, Bjarke ; Geller, Frank ; Gieger, Christian ; Giegling, Ina ; Gordon, Scott D. ; Han, Jiali ; Hansen, Thomas F. ; Hartmann, Annette M. ; Hayward, Caroline ; Heikkilä, Kauko ; Hicks, Andrew A. ; Hirschhorn, Joel N. ; Hottenga, Jouke- Jan ; Huffman, Jennifer E. ; Hwang, Liang-Dar ; Ikram, M. Arfan ; Kaprio, Jaakko ; Kemp, John P. ; Khaw, Kay-Tee ; Klopp, Norman ; Konte, Bettina ; Kutalik, Zoltan ; Lahti, Jari ; Li, Xin ; Loos, Ruth J. F. ; Luciano, Michelle ; Magnusson, Sigurdur H. ; Mangino, Massimo ; Marques-Vidal, Pedro ; Martin, Nicholas G. ; McArdle, Wendy L. ; McCarthy, Mark I. ; Medina-Gomez, Carolina ; Melbye, Mads ; Melville, Scott A. ; Metspalu, Andres ; Milani, Lili ; Mooser, Vincent ; Nelis, Mari ; Nyholt, Dale R. ; O’Connell, Kevin S. ; Ophoff, Roel A. ; Palmer, Cameron ; Palotie, Aarno ; Palviainen, Teemu ; Pare, Guillaume ; Paternoster, Lavinia ; Peltonen, Leena ; Penninx, Brenda W. J. H. ; Polasek, Ozren ; Pramstaller, Peter P. ; Prokopenko, Inga ; Raikkonen, Katri ; Ripatti, Samuli ; Rivadeneira, Fernando ; Rudan, Igor ; Rujescu, Dan ; Smit, Johannes H. ; Smith, George Davey ; Smoller, Jordan W. ; Soranzo, Nicole ; Spector, Tim D. ; Pourcain, Beate St ; Starr, John M. ; Stefánsson, Hreinn ; Steinberg, Stacy ; Teder-Laving, Maris ; Thorleifsson, Gudmar ; Stefánsson, Kári ; Timpson, Nicholas J. ; Uitterlinden, André G. ; van Duijn, Cornelia M. ; van Rooij, Frank J. A. ; Vink, Jaqueline M. ; Vollenweider, Peter ; Vuoksimaa, Eero ; Waeber, Gérard ; Wareham, Nicholas J. ; Warrington, Nicole ; Waterworth, Dawn ; Werge, Thomas ; Wichmann, H.- Erich ; Widen, Elisabeth ; Willemsen, Gonneke ; Wright, Alan F. ; Wright, Margaret J. ; Xu, Mousheng ; Zhao, Jing Hua ; Kraft, Peter ; Hinds, David A. ; Lindgren, Cecilia M. ; Mägi, Reedik ; Neale, Benjamin M. ; Evans, David M. ; Medland, Sarah E.

Izvornik
Nature Human Behaviour (2397-3374) 5 (2020), 1; 59-70

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LANGUAGE DOMINANCE ; LINKAGE ANALYSIS ; METAANALYSIS ; MICROTUBULE ; ASYMMETRY ; AUTISM ; LATERALIZATION ; SCHIZOPHRENIA ; ORIGINS ; SCREEN

Sažetak
Handedness has been extensively studied because of its relationship with language and the over- representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1, 766, 671). We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left- handedness and ambidexterity is low (r(G) = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders. A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Cuellar-Partida, Gabriel; Tung, Joyce Y.; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole A.; Barroso, Inês; Beckmann, Jacques S.; Boks, Marco P.; Boomsma, Dorret I. et al.
Genome-wide association study identifies 48 common genetic variants associated with handedness // Nature Human Behaviour, 5 (2020), 1; 59-70 doi:10.1038/s41562-020-00956-y (međunarodna recenzija, članak, znanstveni)
Cuellar-Partida, G., Tung, J., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O., Barroso, I., Beckmann, J., Boks, M. & Boomsma, D. (2020) Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5 (1), 59-70 doi:10.1038/s41562-020-00956-y.
@article{article, author = {Cuellar-Partida, Gabriel and Tung, Joyce Y. and Eriksson, Nicholas and Albrecht, Eva and Aliev, Fazil and Andreassen, Ole A. and Barroso, In\^{e}s and Beckmann, Jacques S. and Boks, Marco P. and Boomsma, Dorret I. and Boyd, Heather A. and Breteler, Monique M. B. and Campbell, Harry and Chasman, Daniel I. and Cherkas, Lynn F. and Davies, Gail and de Geus, Eco J. C. and Deary, Ian J. and Deloukas, Panos and Dick, Danielle M. and Duffy, David L. and Eriksson, Johan G. and Esko, T\~{o}nu and Feenstra, Bjarke and Geller, Frank and Gieger, Christian and Giegling, Ina and Gordon, Scott D. and Han, Jiali and Hansen, Thomas F. and Hartmann, Annette M. and Hayward, Caroline and Heikkil\"{a}, Kauko and Hicks, Andrew A. and Hirschhorn, Joel N. and Hottenga, Jouke- Jan and Huffman, Jennifer E. and Hwang, Liang-Dar and Ikram, M. Arfan and Kaprio, Jaakko and Kemp, John P. and Khaw, Kay-Tee and Klopp, Norman and Konte, Bettina and Kutalik, Zoltan and Lahti, Jari and Li, Xin and Loos, Ruth J. F. and Luciano, Michelle and Magnusson, Sigurdur H. and Mangino, Massimo and Marques-Vidal, Pedro and Martin, Nicholas G. and McArdle, Wendy L. and McCarthy, Mark I. and Medina-Gomez, Carolina and Melbye, Mads and Melville, Scott A. and Metspalu, Andres and Milani, Lili and Mooser, Vincent and Nelis, Mari and Nyholt, Dale R. and O’Connell, Kevin S. and Ophoff, Roel A. and Palmer, Cameron and Palotie, Aarno and Palviainen, Teemu and Pare, Guillaume and Paternoster, Lavinia and Peltonen, Leena and Penninx, Brenda W. J. H. and Polasek, Ozren and Pramstaller, Peter P. and Prokopenko, Inga and Raikkonen, Katri and Ripatti, Samuli and Rivadeneira, Fernando and Rudan, Igor and Rujescu, Dan and Smit, Johannes H. and Smith, George Davey and Smoller, Jordan W. and Soranzo, Nicole and Spector, Tim D. and Pourcain, Beate St and Starr, John M. and Stef\'{a}nsson, Hreinn and Steinberg, Stacy and Teder-Laving, Maris and Thorleifsson, Gudmar and Stef\'{a}nsson, K\'{a}ri and Timpson, Nicholas J. and Uitterlinden, Andr\'{e} G. and van Duijn, Cornelia M. and van Rooij, Frank J. A. and Vink, Jaqueline M. and Vollenweider, Peter and Vuoksimaa, Eero and Waeber, G\'{e}rard and Wareham, Nicholas J. and Warrington, Nicole and Waterworth, Dawn and Werge, Thomas and Wichmann, H.- Erich and Widen, Elisabeth and Willemsen, Gonneke and Wright, Alan F. and Wright, Margaret J. and Xu, Mousheng and Zhao, Jing Hua and Kraft, Peter and Hinds, David A. and Lindgren, Cecilia M. and M\"{a}gi, Reedik and Neale, Benjamin M. and Evans, David M. and Medland, Sarah E.}, year = {2020}, pages = {59-70}, DOI = {10.1038/s41562-020-00956-y}, keywords = {LANGUAGE DOMINANCE, LINKAGE ANALYSIS, METAANALYSIS, MICROTUBULE, ASYMMETRY, AUTISM, LATERALIZATION, SCHIZOPHRENIA, ORIGINS, SCREEN}, journal = {Nature Human Behaviour}, doi = {10.1038/s41562-020-00956-y}, volume = {5}, number = {1}, issn = {2397-3374}, title = {Genome-wide association study identifies 48 common genetic variants associated with handedness}, keyword = {LANGUAGE DOMINANCE, LINKAGE ANALYSIS, METAANALYSIS, MICROTUBULE, ASYMMETRY, AUTISM, LATERALIZATION, SCHIZOPHRENIA, ORIGINS, SCREEN} }
@article{article, author = {Cuellar-Partida, Gabriel and Tung, Joyce Y. and Eriksson, Nicholas and Albrecht, Eva and Aliev, Fazil and Andreassen, Ole A. and Barroso, In\^{e}s and Beckmann, Jacques S. and Boks, Marco P. and Boomsma, Dorret I. and Boyd, Heather A. and Breteler, Monique M. B. and Campbell, Harry and Chasman, Daniel I. and Cherkas, Lynn F. and Davies, Gail and de Geus, Eco J. C. and Deary, Ian J. and Deloukas, Panos and Dick, Danielle M. and Duffy, David L. and Eriksson, Johan G. and Esko, T\~{o}nu and Feenstra, Bjarke and Geller, Frank and Gieger, Christian and Giegling, Ina and Gordon, Scott D. and Han, Jiali and Hansen, Thomas F. and Hartmann, Annette M. and Hayward, Caroline and Heikkil\"{a}, Kauko and Hicks, Andrew A. and Hirschhorn, Joel N. and Hottenga, Jouke- Jan and Huffman, Jennifer E. and Hwang, Liang-Dar and Ikram, M. Arfan and Kaprio, Jaakko and Kemp, John P. and Khaw, Kay-Tee and Klopp, Norman and Konte, Bettina and Kutalik, Zoltan and Lahti, Jari and Li, Xin and Loos, Ruth J. F. and Luciano, Michelle and Magnusson, Sigurdur H. and Mangino, Massimo and Marques-Vidal, Pedro and Martin, Nicholas G. and McArdle, Wendy L. and McCarthy, Mark I. and Medina-Gomez, Carolina and Melbye, Mads and Melville, Scott A. and Metspalu, Andres and Milani, Lili and Mooser, Vincent and Nelis, Mari and Nyholt, Dale R. and O’Connell, Kevin S. and Ophoff, Roel A. and Palmer, Cameron and Palotie, Aarno and Palviainen, Teemu and Pare, Guillaume and Paternoster, Lavinia and Peltonen, Leena and Penninx, Brenda W. J. H. and Polasek, Ozren and Pramstaller, Peter P. and Prokopenko, Inga and Raikkonen, Katri and Ripatti, Samuli and Rivadeneira, Fernando and Rudan, Igor and Rujescu, Dan and Smit, Johannes H. and Smith, George Davey and Smoller, Jordan W. and Soranzo, Nicole and Spector, Tim D. and Pourcain, Beate St and Starr, John M. and Stef\'{a}nsson, Hreinn and Steinberg, Stacy and Teder-Laving, Maris and Thorleifsson, Gudmar and Stef\'{a}nsson, K\'{a}ri and Timpson, Nicholas J. and Uitterlinden, Andr\'{e} G. and van Duijn, Cornelia M. and van Rooij, Frank J. A. and Vink, Jaqueline M. and Vollenweider, Peter and Vuoksimaa, Eero and Waeber, G\'{e}rard and Wareham, Nicholas J. and Warrington, Nicole and Waterworth, Dawn and Werge, Thomas and Wichmann, H.- Erich and Widen, Elisabeth and Willemsen, Gonneke and Wright, Alan F. and Wright, Margaret J. and Xu, Mousheng and Zhao, Jing Hua and Kraft, Peter and Hinds, David A. and Lindgren, Cecilia M. and M\"{a}gi, Reedik and Neale, Benjamin M. and Evans, David M. and Medland, Sarah E.}, year = {2020}, pages = {59-70}, DOI = {10.1038/s41562-020-00956-y}, keywords = {LANGUAGE DOMINANCE, LINKAGE ANALYSIS, METAANALYSIS, MICROTUBULE, ASYMMETRY, AUTISM, LATERALIZATION, SCHIZOPHRENIA, ORIGINS, SCREEN}, journal = {Nature Human Behaviour}, doi = {10.1038/s41562-020-00956-y}, volume = {5}, number = {1}, issn = {2397-3374}, title = {Genome-wide association study identifies 48 common genetic variants associated with handedness}, keyword = {LANGUAGE DOMINANCE, LINKAGE ANALYSIS, METAANALYSIS, MICROTUBULE, ASYMMETRY, AUTISM, LATERALIZATION, SCHIZOPHRENIA, ORIGINS, SCREEN} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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