Naslov
Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report

Autori
Primorac, Dragan ; Stojanović Stipić, Sanda ; Strbad, Marko ; Girandon, Lenart ; Barlič, Ariana ; Ivić, Ivo ; Marasović Krstulović, Daniela ; Jukić, Irena ; Halassy, Beata ; Hećimović, Ana ; Matišić, Vid ; Molnar, Vilim

Izvornik
Croatian Medical Journal (1332-8166) 62 (2021), 3; 288-296

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells

Sažetak
COVID-19 presentations range from cold-like symptoms to severe symptoms with the development of acute respiratory distress syndrome (ARDS). We report on a severe COVID-19 patient who was mechanically ventilated and who developed ARDS and bacterial infection. Because of rapid clinical deterioration and the exhaustion of other treatment options, the family and attending physicians requested a compassionate use of adult allogeneic bone marrow-derived mesenchymal stem cells (MSC) in addition to commonly used immunosuppressive, antiviral, and supportive therapy. The clinical course is discussed thoroughly, with a special emphasis on the safety and effect of MSC therapy. Compassionate MSC treatment, given in three rounds, affected ARDS regression. The patient was discharged from the intensive care unit after 31 days and from hospital after 49 days in a good general condition. MSC treatment was not associated with any side effects and was well tolerated in a three-week period ; therefore, it should be studied in larger trials and considered for compassionate use.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA