Naslov
Non-Myelofibrosis Chronic Myeloproliferative Neoplasm Patients Show Better Seroconversion Rates after SARS-CoV-2 Vaccination Compared to Other Hematologic Diseases: A Multicentric Prospective Study of KroHem

Autori
Sertić, Zrinka ; Lucijanić, Marko ; Bašić-Kinda, Sandra ; Serventi Seiwerth, Ranka ; Periša, Vlatka ; Sertić, Dubravka ; Coha, Božena ; Pulanić, Dražen ; Perić, Zinaida ; Desnica, Lana ; Mikulić, Mirta ; Vodanović, Marijo ; Radman-Livaja, Ivo ; Šegulja, Dragana ; Rogić, Dunja ; Valković, Toni ; Aurer, Igor ; Duraković, Nadira

Kolaboracija
KroHem

Izvornik
Biomedicines (2227-9059) 10 (2022), 11; 2892, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SARS-CoV-2 vaccination ; COVID-19 ; chronic myeloproliferative neoplasms ; chronic myeloid leukemia ; non-Hodgkin’s lymphoma ; chronic lymphocytic leukemia ; humoral immune response ; anti-CD20 monoclonal antibody

Sažetak
Disease- and treatment-mediated immunodeficiency might render SARS-CoV-2 vaccines less effective in patients with hematologic diseases. We performed a prospective non- interventional study to evaluate humoral response after one and two doses of mRNA- 1273, BNT162b2, or ChAdOx1 nCoV-19 vaccine in 118 patients with different malignant or non-malignant hematologic diseases from three Croatian treatment centers. An electrochemiluminescent assay was used to measure total anti-SARS-CoV-2 S-RBD antibody titers. After one vaccine dose, 20/66 (33%) achieved seropositivity with a median antibody titer of 6.1 U/mL. The response rate (58/90, 64.4%) and median antibody titer (>250 U/mL) were higher after two doses. Seropositivity varied with diagnosis (overall p < 0.001), with the lowest rates in lymphoma (34.6%) and chronic lymphocytic leukemia (52.5%). The overall response rate in chronic myeloproliferative neoplasms (CMPN) was 81.3% but reached 100% in chronic myeloid leukemia and other non- myelofibrosis CMPN. At univariable analysis, age > 67 years, non-Hodgkin’s lymphoma, active treatment, and anti-CD20 monoclonal antibody therapy increased the likelihood of no vaccine response, while hematopoietic stem cell recipients were more likely to respond. Age and anti-CD20 monoclonal antibody therapy remained associated with no response in a multivariable model. Patients with the hematologic disease have attenuated responses to SARS-CoV-2 vaccines, and significant variations in different disease subgroups warrant an individualized approach.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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