Naslov
Feasibility of obinutuzumab (G) combined with higher doses of chlorambucil (Clb) for frontline treatment of CLL: a retrospective non-interventional study of KroHem, the Croatian Cooperative Group for Hematologic Diseases

Autori
Aurer, Igor ; Jakšić, Ozren ; Basic-Kinda, Sandra ; Mišura Jakobac, Karla ; Sinčić-Petričević, Jasminka ; Novaković Coha, Sabina ; Galušić, Davor ; Holik, Hrvoje ; Valković, Toni ; Županić-Krmek, Dubravka ; Dragicevic, Ida Hude ; Milunović, Vibor ; Pejša, Vlatko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, stručni

Izvornik
XVIII International Workshop on Chronic Lymphocytic Leukemia 2019 / Leukemia & lymphoma, 61(S1) / - , 2020, 111-112

Skup
18th International Workshop on Chronic Lymphocytic Leukemia 2019

Mjesto i datum
Edinburgh, Ujedinjeno Kraljevstvo, 20.09.2019. - 23.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
KroHem ; obinutuzumab (G) ; chlorambucil (Clb)

Sažetak
Prolonged steroid premedication and/or reduction of lymphocyte count with Clb prior to administering first dose of G might result in a lower frequency of severe infusion reactions observed in our series In contrast to rituximab, the combination of G with higher-doses of Clb frequently results in premature stopping of the latter, especially in patients with serious comorbidities. This prevents the delivery of the intended total dose of Clb and reduces the possibility to improve efficacy over G þ Clb pulses.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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