Naslov
Selection, validation, and utilization of mitogenome SNP array information in cattle breeding

Autori
Brajkovic, Vladimir ; Bradic, Leona ; Turkalj, Katarina ; Novosel, Dinko ; Ristov, Strahil ; Ajmone-Marsan, Paolo ; Colli, Licia ; Cubric- Curik, Vlatka ; Solkner, Johann ; Curik, Ino

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP) / - , 2022, 2826-2829

Skup
12th World Congress on Genetics Applied to Livestock Production (WCGALP)

Mjesto i datum
Rotterdam, Nizozemska, 03.07.2022. - 08.07.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Mitogenome ; SNPs ; Selection ; Validation ; Utilization

Sažetak
High-density SNP arrays are routinely used for genetic improvement of livestock populations. At the same time, mitogenome SNPs have rarely been used. In this study, we empirically evaluated 331 mitogenome SNPs included in the GGP Bovine 100K SNP array developed in collaboration with NEOGEN Genomics (Lincoln, NE, USA). Here we present a pipeline for the potential use of mitogenome SNPs with some examples: i) classification of haplogroups with emphasis on rare ones (I, P, Q, R and T5), ii) pedigree verification iii) pedigree and haplotype imputation, iiii) deleterious mutation detection iv) mitogenome and nuclear diversity, and v) standard mitogenome classification and phylogenetics. In summary, 317 mitogenome SNPs have been successfully validated and contribute as additional information to autosomal markers in population genomic analyses. We believe that our study will help to promote the use of mitogenome information in cattle breeding and biodiversity management.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Poljoprivreda (agronomija), Interdisciplinarne biotehničke znanosti

POVEZANOST RADA