Naslov
External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis

Autori
Gazda, Jakub ; Janicko, Martin ; Drazilova, Sylvia ; Grgurevic, Ivica ; Kanizaj, Tajana Filipec ; Koller, Tomas ; Bodorovska, Beatrica ; Mijic, Maja ; Mikolašević, Ivana ; Stromar, Ivana Knezevic ; Kucinsky, Branislav ; Gazda, Matej ; Jarcuska, Peter

Izvornik
Canadian Journal of Gastroenterology and Hepatology (2291-2789) 22 (2021); 9928065, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Liver Cirrhosis, Biliary / drug therapy ; Ursodeoxycholic Acid / therapeutic use

Sažetak
Background: Ursodeoxycholic acid response score (URS) is a prognostic model that estimates the baseline probability of treatment response after 12 months of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cholangitis (PBC). Aim: To independently evaluate the predictive performance of the URS model. Methods: We used a cohort of Slovak and Croatian treatment-naïve PBC patients to quantify the discrimination ability using the area under receiver operating characteristic curve (AUROC) and its 95% confidence interval (CI). Furthermore, we evaluated the calibration using calibration belts. The primary outcome was treatment response after 12 months of UDCA therapy defined as values of alkaline phosphatase ≤1.67 × upper limit of normal. Results: One hundred and ninety-four patients were included. Median pretreatment age was 56 years (interquartile range 49-62). Treatment response was achieved in 79.38% of patients. AUROC of the URS was 0.81 (95% CI 0.73-0.88) and the calibration belt revealed that response rates were correctly estimated by predicted probabilities. Conclusion: Our results confirm that the URS can be used in treatment-naïve PBC patients for estimating the treatment response probability after 12 months of UDCA therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA