Naslov
Fetuin-A deficiency but not pentraxin 3, FGF-21, or irisin, predisposes to more serious COVID-19 course
(Fetuin-A deficiency but not pentraxin 3, FGF-21, or irisin, predisposes to more serious COVID-19 course)

Autori
Kukla, Michał ; Menżyk, Tomasz ; Dembiński, Marcin ; Winiarski, Marek ; Garlicki, Aleksander ; Bociąga-Jasik, Monika ; Skonieczna, Magdalena ; Hudy, Dorota ; Maziarz, Barbara ; Kuśnierz-Cabala, Beata ; Kapusta, Maria ; Skladany, Lubomir ; Grgurević, Ivica ; Mikolašević, Ivana ; Filipec-Kanižaj, Tajana ; Wójcik-Bugajska, Małgorzata ; Grodzicki, Tomasz ; Rogula, Tomasz ; Stygar, Dominika

Izvornik
Biomolecules (2218-273X) 11 (2021), 10; 1422, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
coronavirus disease 2019 (COVID-19) ; fetuin-A ; fibroblast growth factor 21 (FGF-21) ; irisin ; pentraxin 3 (PTX3) ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Sažetak
Analysis of liver biopsy specimens showed that SARS- CoV-2 might have led to liver damage. This study aimed to evaluate the role of selected hepatokines and myokines in the development and progression of COVID-19. Seventy patients with laboratory-confirmed COVID-19 and 20 healthy volunteers were enrolled in the study. Irisin, pentraxin 3, fetuin-A, and FGF-21 serum concentrations and biochemical parameters were assessed using an immunoenzymatic method with commercially available enzyme immunoassay (EIA) or enzyme-linked immunosorbent assay (ELISA) kits. Serum fetuin-A concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers. The serum concentration of FGF-21 was significantly increased in obese COVID-19 patients compared to overweight ones. Moreover, the FGF-21 level was higher in COVID-19 patients diagnosed with metabolic syndrome than in patients without metabolic syndrome. PTX3 concentration was higher in COVID-19 patients with higher HOMA-IR values than those with lower HOMA-IR values. COVID-19 patients with HOMA-IR ≤ 3 and >3 had significantly lower fetuin-A levels than the control group. Irisin concentration was significantly decreased in the HOMA-IR ≤ 3 COVID-19 subgroup when comparing with the control group. Lower levels of fetuin-A observed in COVID-19 patients despite higher HOMA-IR, CRP, and ferritin levels, pneumonia, patients requiring ICU care suggests that fetuin-A deficiency predisposes to more severe COVID- 19 course. Upregulated pentraxin 3 may be used as a potential predictor of COVID-19 severity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA