Naslov
A prelude into the order of magnitude

Autori
Medvedec, Mario ; Dodig, Damir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European Journal of Nuclear Medicine and Molecular Imaging, Supplement 2 / Ell, Peter J. - Berlin : Springer, 2003

Skup
Annual Congress of European Association of Nuclear Medicine

Mjesto i datum
Amsterdam, Nizozemska, 23.08.2003. - 27.08.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
thyroid disease; radioiodine therapy; thyroid stunning
(bolest štitnjače; radiojodna terapija; ošamućenje štitnjače)

Sažetak
Aim: The objective of this study was to derive, compile and compare dosimetric data from the literature on malignant and benign thyroid diseases, in order to shed more light upon the effect of thyroid stunning caused by radiation absorbed dose of radioiodine. Material and Methods: A logarithmic regression analysis was applied to fit the curves representing the extent of thyroid stunning in thyroid cancer patients in dependence on the radiation absorbed dose of diagnostic radioiodine-131, as derived from the studies by Jeevanram et al. (Nucl Med Biol, 1986) (1), Medvedec et al. (Eur J Nucl Med, 2000) (2) and Sinyuta et al. (Eur J Nucl Med, 2001) (3). The regression curves were fitted by using the mean values given for three (1, 2) and four (3) groups of patients and were compared with the corresponding logarithmic curve found in patients given two-step radioiodine-131 therapy for benign thyroid disease (Sabri et al, Eur J Nucl Med, 2000) (4). Results: According to the regression models, thyroid stunning is 0% if thyroid radiation absorbed dose is up to about 4 Gy (1, 2, 3) and 35 Gy (4) in malignant and benign conditions, respectively. In thyroid cancer patients Behr et al. (J Nucl Med 2001) (5) suggested a similar treshold value (6 Gy). Thyroid stunning amounts to 50% or more in case of 30 Gy (1, 2, 3) and 500 Gy (4) delivered in malignant and benign conditions, respectively. Conclusion: From the latest dosimetric advances, it seems that the radiation absorbed dose treshold for thyroid stunning in malignant thyroid disease (1, 2, 3, 5) is at least an order of magnitude lower than in benign thyroid disease (4). Therefore, it is not recommended to deliver more than a few Gy into the target tissue in thyroid cancer patients. More studies are required to confirm the treshold values in benign thyroid conditions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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