Naslov
House Dust Mite Subcutaneous Immunotherapy Does Not Induce New Sensitization to Tropomyozin: Does It Do the Opposite?

Autori
Pevec, Branko ; Radulović Pevec, Mira ; Stipić Marković, Asja ; Batišta, Irena

Izvornik
Journal of investigational allergology and clinical immunology (1018-9068) 24 (2014), 1; 29-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
House dust mite ; Seafood ; Sensitization ; Specific immunotherapy ; Tropomyosin

Sažetak
Results: sIgE to tropomyosin was found in only 5 patients, 3 of whom expressed low and clinically irrelevant levels of sIgE to Der p 10, while sIgE to Pen a 1 was not found. The remaining 2 patients expressed sIgE to both tropomyosins. In the first, the initial increase and subsequent decrease resembled the dynamics of the IgE antibodies usually seen in SCIT patients and were never accompanied by seafood-induced symptoms. In the other, a decrease in levels of sIgE to both tropomyosins resulted in the complete loss of his reactivity toward seafood. Conclusions: Immunotherapy using HDM extracts does not induce clinically relevant sensitization to tropomyosin. In certain cases of combined mite and seafood allergy, treatment may even lead to the improvement of food allergy symptoms. The levels of sIgE to Der p 10 and Pen a 1 may be useful monitoring marker

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA