Naslov
Influence of urban (city of Zagreb) and rural (National park Lonjsko polje) environment in allergic diseases

Autori
Toplalušić, Iva ; Stipić Marković, Asja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of MESIA 2019 / - , 2019, 71-71

Skup
4th Meeting of Middle European Societies for Immunology and Allergology (MESIA 2019)

Mjesto i datum
Šamorín, Slovačka, 28.11.2019. - 30.11.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
allergic diseases ; environment

Sažetak
Increasing trends in the prevalence of allergic diseases of affluent countries, encouraged worldwide studies on environmental influence in immunoregulation. Some factors have been identified as high risk, e.g. maternal smoking and respiratory viruses in the pathogenesis of asthma, while some other, like breastfeeding, are known as protective. The most consistent findings of protective lifestyle are those of rural environment, especially for asthma and atopic dermatitis, while this is less clear for allergic rhinitis and allergic sensitization. The underlying mechanisms are not completely understood, but it has recently been demonstrated that rural environment has a role in innate immunity. Due to genetic differences, it is very important to perform national epidemiological studies, in order to plan preventive strategies. During the school year 2017/2018, we completed a huge epidemiological study on allergic diseases ; asthma, atopic dermatitis, allergic rhinitis and allergic sensitization, in two regions of Croatia: urban (city of Zagreb) and rural (National park Lonjsko polje). More than 1700 school children aged 6-14 years old participated in the study. We used standardised ISAAC (International Study on Allergy and Asthma) questionnaires on symptoms, as well as skin prick tests with standard set of inhalant allergens.Results showed protective role of biodiverse environment on allergic diseases, which was strongly expressed for allergic rhinitis and atopic dermatitis symptoms. Odds ratios for developing these two entities during a 12-month period were lower for all age groups of the children from the Lonjsko polje area. Children from Lonjsko polje also used medications and visited pharmacists less often than those from the city of Zagreb. Regarding asthma symptoms, there was no difference in odds ratios between the two groups, except for a variable wheezing ever in a life for a 13-14 years-old age group. A number of positive skin prick tests was also higher in children from the city of Zagreb. Further research should be focused on genetic-environmental interplays in this region and microbiome analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA