Naslov
Allergic conditions along rural-urban gradient in the study of Croatian school pop

Autori
Stipić Marković, Asja ; Topalušić, Iva

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
7 th Slovenian pneumology, allergology and immunology congress ; online : book of abstracts / - Mitja Košnik, 2020

ISBN
978-961-95041-1

Skup
7th Slovenian pneumology, allergology and immunology congress

Mjesto i datum
Golnik, Slovenia, 10.12.2020. - 12.12.2020

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
allergy ; rural ; urban ; school children

Sažetak
Background: Urbanisation delays postnatal maturation of adaptive immunity. Interplaying with genetical determinants it is drammatically increasing the risk for all types of allergy, especially among children. Rural living comprises protective (not fully understood) immunomodulatory factors inducing immunotolerance. The main aim of our study was to investigate prevalence differences in asthma (A), rhinitis (AR) and atopic dermatitis (AD) symptoms between three age groups of children living in the city of Zagreb and children living in Natural Park Lonjsko Polje, complex of lowland riparian forests with 1500 species living there. Second, we intend to get insight into differences of some urban/rural early-life environmental exposures assessed from ISAAC questionnaires. Patients and methods: In the schoolyear 2017/2018 total of 1745 schoolchildren aged 6-14 years (6-7 yrs, 10-11 yrs and 13-14 yrs age groups), from 39 randomly selected elementary schools, were included. Questionnaires were answered by parents. The results were compared with the study in Zagreb in year 2002. Results: Regarding allergic rhinitis, children from rural setting showed lower risk for current AR (last 12- months symptoms) (OR 0, 373 ; 0, 563 ; 0, 172 for all age groups respectivelly) in comparison to the children from the urban area who reported more drugs usage for current AR (X2 Yates corect 0, 46, p <0, 0001), and more often pharmacies visits (p<0, 046). The responses for asthma are different from the data seen in rhinitis. There was no difference between rural and urban three-age- groups-children current and ever in lifetime asthma. However, the meaning of more frequent urban wheezing ever in a lifetime in the oldest, 13-14 years old age group, is not clear. There are literature evidences of strong genetic relationship in AD. Our study showed different environmental influences on current AD symptoms which are strongly associated with urban life- style and medication consumption. That is opposite in children living in rural area of Lonjsko Polje for all age groups. History of allergic diseases in both parents (mother´s AR and father´s AD) are risk factors for current AD in the city while cooked green vegetables were protective.Conclusion: Comparisson of rural/urban risks for AR, A and AD symptoms has shown complex and different patterns of environmental associations with distinct type of allergic disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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