Naslov
PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke

Autori
A Bazina 1, J Sertić 2, A Mišmaš 3, T Lovrić 4, Z Poljaković 5, D Miličić 6

Izvornik
Gene (0378-1119) 2 (2015), 560; 200-204

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Odrasli, Geni, Ishemijski moždani udar, Polimorfizam
(Adults ; Genes ; Ischemic stroke ; Polymorphisms.)

Sažetak
Aim: Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-γ and IL-6 gene variants on IS onset. Material and methods: A total of 301 subjects (144 males, 157 females) participated in the study, 114 patients with IS and 187 healthy controls. Results: Statistically significant predictors of IS were male gender (OR 7.13, 95% CI 2.92-17.39, p<0.001), hypertension (OR 7.82. 95% CI 2.53- 24.19, p<0.001), lowered HDL cholesterol (OR 8.20, 95% CI 2.41-27.94, p=0.001), elevated C- reactive protein (OR 5.26, 95% CI 1.92-14.41) and IL-6 -174 GC (OR 2.44 95% CI 1.01-5.91, p=0.0048) genotype. Males, compared to females, had 7 times higher odds for stroke. IL6 -174G/C genotype increased the odds for IS for 2.4 times. PPARγ was not statistically significantly associated with stroke. Conclusion: We can point to the IL-6 -174G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA