Naslov
Confirmation of CD19+ B-Lymphocyte Depletion Prior to Intake of the Second Dose of Ocrelizumab in Multiple Sclerosis Patients

Autori
Radmilo, Marija ; Pavelin, Sanda ; Vujović, Igor ; Šoda, Joško ; Rogić Vidaković, Maja

Izvornik
Biomedicines (2227-9059) 11 (2023), 2; 353, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
multiple sclerosis ; ocrelizumab ; immunophenotyping ; B-lymphocytes ; T-lymphocytes ; NK cells ; albumins ; globulins

Sažetak
The aim of the retrospective study was to compare the immunophenotyping of T-lymphocytes, B-lymphocytes, and natural killer cells before the administration of the first and the second dose of ocrelizumab in 22 patients with multiple sclerosis in a three-year period (2019–2021) at the Department of Neurology of the University Hospital of Split. The values of cell immunophenotyping and protein electrophoresis, as well as laboratory parameters, were investigated. There was no significant decrease in serum albumin and globulins before the second dose of ocrelizumab (p >0, 05). A decrease in the number of T-lymphocytes before administration of the second dose of oc- relizumab was observed, but without statistical significance (p = 0.274). Significant depletion occurred in median CD19+ B-lymphocytes (p < 0.001) before the intake of the second dose of ocreli- zumab confirming the primary action of ocrelizumab on the B cell lineage.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA