Naslov
Elastographic parameters of liver steatosis and fibrosis predict independently the risk of incident chronic kidney disease and acute myocardial infarction in patients with type 2 diabetes mellitus

Autori
Mikolasevic, I. ; Domislovic, V. ; Ruzic, A. ; Hauser, G. ; Rahelic, D. ; Klobucar-Majanovic, S. ; Krznaric, Z. ; Dobrila-Dintinjana, R. ; Grgurevic, I. ; Skenderevic, N. ; Lukic, A. ; Targher, G.

Izvornik
Journal of diabetes and its complications (1056-8727) 36 (2022), 8; 108226, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Controlled attenuation parameter ; Diabetic complications ; Liver stiffness measurement ; Nonalcoholic fatty liver disease ; Prospective ; Type 2 diabetes

Sažetak
Aims: The aim of this prospective study was to examine the relationship between controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) with the risk of developing a composite endpoint inclusive of incident acute myocardial infarction (AMI), cerebrovascular insult (CVI) or chronic kidney disease (CKD) in people with type 2 diabetes mellitus (T2DM). Methods: This study included 238 T2DM outpatients without chronic liver diseases. Results: The patient population was followed for a median period of 7.6 years. Kaplan- Meier survival analyses showed that there was a higher proportion of patients who developed the aforementioned composite outcome (P < 0.001 by the log-rank test), as well as CKD (P < 0.001) or AMI alone (P = 0.014) among those with elevated CAP values (≥238 dB/m) at baseline. Similarly, Kaplan- Meier survival analyses showed that there was a higher proportion of patients who developed the composite outcome (P < 0.001), as well as CKD (P < 0.001), or AMI alone (P < 0.001) among those with elevated LSM values (≥7.0/6.2 kPa). In multivariable regression analyses, the presence of elevated CAP (adjusted-hazard ratio 2.34, 95% CI 1.32-4.15) and elevated LSM (adjusted- hazard ratio 2.84, 95% CI 1.92-4.21), independently of each other, were associated with a higher risk of developing the composite outcome, as well as incident AMI or CKD alone after adjusting for traditional cardiovascular risk factors and diabetes-related variables. Conclusions: Our study shows that the elastographic parameters of liver steatosis and fibrosis independently predict the long-term risk of developing chronic vascular complications in T2DM patients.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

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