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Pregled bibliografske jedinice broj: 1247893

Thermodynamics of anion binding by pentaphenylalanine in acetonitrile


Modrušan, Matija; Otmačić, Lucija; Vidović, Nikolina; Cindro, Nikola; Crnolatac, Ivo; Speranza, Giovanna; Horvat, Gordan; Tomišić, Vladislav
Thermodynamics of anion binding by pentaphenylalanine in acetonitrile // Solutions in chemistry 2022 : book of abstracts / Kassal, Petar ; Meštrović, Ernest ; Namjesnik, Danijel ; Ribić, Rosana ; Šekutor, Marina ; Tomišić, Vladislav ; Usenik, Andrea (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2022. str. 107-107 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 1247893 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Thermodynamics of anion binding by pentaphenylalanine in acetonitrile

Autori
Modrušan, Matija ; Otmačić, Lucija ; Vidović, Nikolina ; Cindro, Nikola ; Crnolatac, Ivo ; Speranza, Giovanna ; Horvat, Gordan ; Tomišić, Vladislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Solutions in chemistry 2022 : book of abstracts / Kassal, Petar ; Meštrović, Ernest ; Namjesnik, Danijel ; Ribić, Rosana ; Šekutor, Marina ; Tomišić, Vladislav ; Usenik, Andrea - Zagreb : Hrvatsko kemijsko društvo, 2022, 107-107

ISBN
978-953-8334-05-4

Skup
International Conference Solutions in Chemistry 2022

Mjesto i datum
Sveti Martin na Muri, Hrvatska, 08.11.2022. - 11.11.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
anion binding ; circular dichroism ; MD simulation ; NMR ; thermodynamics

Sažetak
Cyclic peptides represent a large and underexploited class of drug discovery candidates. Their improved metabolic stability and binding affinity, in comparison with linear analogues, result in greater resistance to enzymatic hydrolysis, increased bioavailability, and bioactivity. In the synthesis of cyclic peptides, the main factor that affects the yield of a ring- closure reaction is the conformational preorganization, i.e. the ability of a linear precursor to adopt quasi-cyclic conformation in which the N– and C– termini are in a close proximity. One approach to achieve that is to use templating agents, such as anions, that can bind to linear precursors as well as cyclic peptides. In the scope of this work, we studied the binding of inorganic anions to pentaphenylalanine methyl ester in acetonitrile by means of 1H NMR, fluorimetric, and CD titrations. In addition, we carried out the MD simulations to get insight into the structural changes which occur upon anion binding to pentapeptide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-9560 - Koordinacijske reakcije makrocikličkih liganada u otopini (MacroSol) (Tomišić, Vladislav, HRZZ - 2019-04) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

solutionsinchemistry.hkd.hr

Citiraj ovu publikaciju:

Modrušan, Matija; Otmačić, Lucija; Vidović, Nikolina; Cindro, Nikola; Crnolatac, Ivo; Speranza, Giovanna; Horvat, Gordan; Tomišić, Vladislav
Thermodynamics of anion binding by pentaphenylalanine in acetonitrile // Solutions in chemistry 2022 : book of abstracts / Kassal, Petar ; Meštrović, Ernest ; Namjesnik, Danijel ; Ribić, Rosana ; Šekutor, Marina ; Tomišić, Vladislav ; Usenik, Andrea (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2022. str. 107-107 (poster, nije recenziran, sažetak, znanstveni)
Modrušan, M., Otmačić, L., Vidović, N., Cindro, N., Crnolatac, I., Speranza, G., Horvat, G. & Tomišić, V. (2022) Thermodynamics of anion binding by pentaphenylalanine in acetonitrile. U: Kassal, P., Meštrović, E., Namjesnik, D., Ribić, R., Šekutor, M., Tomišić, V. & Usenik, A. (ur.)Solutions in chemistry 2022 : book of abstracts.
@article{article, author = {Modru\v{s}an, Matija and Otma\v{c}i\'{c}, Lucija and Vidovi\'{c}, Nikolina and Cindro, Nikola and Crnolatac, Ivo and Speranza, Giovanna and Horvat, Gordan and Tomi\v{s}i\'{c}, Vladislav}, year = {2022}, pages = {107-107}, keywords = {anion binding, circular dichroism, MD simulation, NMR, thermodynamics}, isbn = {978-953-8334-05-4}, title = {Thermodynamics of anion binding by pentaphenylalanine in acetonitrile}, keyword = {anion binding, circular dichroism, MD simulation, NMR, thermodynamics}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Sveti Martin na Muri, Hrvatska} }
@article{article, author = {Modru\v{s}an, Matija and Otma\v{c}i\'{c}, Lucija and Vidovi\'{c}, Nikolina and Cindro, Nikola and Crnolatac, Ivo and Speranza, Giovanna and Horvat, Gordan and Tomi\v{s}i\'{c}, Vladislav}, year = {2022}, pages = {107-107}, keywords = {anion binding, circular dichroism, MD simulation, NMR, thermodynamics}, isbn = {978-953-8334-05-4}, title = {Thermodynamics of anion binding by pentaphenylalanine in acetonitrile}, keyword = {anion binding, circular dichroism, MD simulation, NMR, thermodynamics}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Sveti Martin na Muri, Hrvatska} }




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