Naslov
Relationship between terbinafine dose and complete cure rate in tinea capitis

Autori
Friedlander Falon S. ; Skerlev, Mihael ; Lipozenčić, Jasna ; Bretz, F. ; Emady-Azar, S. ; Gourmala, N. ; Padi, C.

Izvornik
Annales de Dermatologie et de Venereologie (0151-9638) 129 (2002);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, stručni

Ključne riječi
Tinea capitis; terbinafine; complete cure rates

Sažetak
Griseofulvin is the standad treatment for tinea capitis, however the required long treatment (6-8 weeks) may hinder compliance. The possibility that shorter courses of terbinafine are effective was investigated in 2 multicenter, Phase II, randomized, controlled durationfinding trials in 268 children with tinea capitis. At doses extrapolated from the adult literature (3-6 mg/kg), terbinafine was effective, safe and well tolerated. Complete cure rates were 57 for Trichopyton tinea capitis ( 4 weeks treatment) and 62% for Microsporum (6wks). The effect of treatment duration on cure rates was modest. We developed a logistic model, based on data from the 2 trials, to investigate a potential dose - response relationship. Pharmacokinetic data indicate that children have a high clearance rate, thus doses to 10 mg/kg would result in a level of exopsure which is comparable to adults treated with 250 - 400 mg/day. Dose-response modelling showed a significantlinear relationship (p= 0, 03) between complete cure rates and terbinafine dose. Patients treated with doses > 4, 5 and < 4, 5 mg/kg achived cure rates of 53, 9% and 43, 5% respectively, regardless of treatment duration (T and M. species combined). The model predicted complete cure rates of 77-87%at doses 9-12mg/kg. This stady sugegests that complete cure rates of > 75% may be achieved by increasing terbinafine dose while remaining within an acceptable safety profile and possibly, with shorter treatment durations thangriseofulvin. Further studies are required to confirm these findings.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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