Naslov
Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60

Autori
Martinović Bazina, Antonela ; Merkler, Ana ; Ćelić, Ivan ; Starčević, Katarina ; Šimić, Mirjana ; Karmelić, Ivana ; Poljaković, Zdravka ; Kalinić, Dubravka ; Sertić, Jadranka

Izvornik
Gene (0378-1119) 809 (2022), 9; 146029, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ishemic stroke ; serum CRP level ; PPAG CC genotype

Sažetak
Aim The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS). Material and methods A total of 114 patients with IS and 135 healthy controls were included. Results After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-γ had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. In participants with PPAR CG or GG genotype level of CRP and IS were not statistically significantly associated (OR = 1.00 ; 95% CI 0.90–1.10 ; p = 0.933), but in participants with PPAR CC genotype, the association of serum CRP level and IS was significant (OR = 1.67 ; 95% CI 1.21–2.31 ; p = 0.002). Conclusion In patients with PPAR CC genotype the association of serum CRP level and IS was significant.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA