Naslov
Heritabilities of Ocular Biometrical Traits in Two Croatian Isolates with Extended Pedigrees

Autori
Vitart, Veronique ; Bencic, Goran ; Hayward, Caroline ; Herman, Jelena Škunca ; Huffman, Jennifer ; Campbell, Susan ; Bucan, Kajo ; Zgaga, Lina ; Kolcic, Ivana ; Polašek, Ozren ; Campbell, Harry ; Wright, Alan ; Vatavuk, Zoran ; Rudan, Igor

Izvornik
Investigative Opthalmology &amp ; Visual Science (1552-5783) 51 (2010), 2; 737-743

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genetic studies ; keratometry ; biometry ; genome-wide ; Korčula ; Vis

Sažetak
To assess the effects of body stature and years of education, in addition to age and sex, on six oculometric traits and to estimate the heritabilities of these quantitative traits in two Croatian cross-population studies. METHODS. Adult subjects living on the two Croatian islands of Vis and Korcˇula were recruited for a large epidemiologic and genetic study that included eye biometry, keratometry, and autorefraction. Effects and heritabilities were estimated by using general linear mixed models for axial length (AL), anterior chamber depth (ACD), corneal curvature (CC), corneal thickness (CT), lens thickness (LT), and spherical equivalent refraction (SER). Both cohorts were genotyped with dense SNP arrays, allowing the use of kinship coefficients derived from genotypic data (realized kinship) rather than from pedigree information (expected kinship). RESULTS. Across cohorts, body mass index (BMI) did not consistently influence any of the ocular traits adjusted for age and/or sex, whereas height and years in education (YrEd) did, explaining up to an additional 5% of the variance (in CC). CT was the trait least influenced by covariates. Estimated heritabilities in Vis and Korcˇula, respectively, were 84% and 52% for CC, 75% and 71% for CT, 37% and 32% for LT, 59% and 45% for ACD, 37% and 74% for AL, and 0% and 17% for SER.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA