Pregled bibliografske jedinice broj: 1246441
Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study // International journal of molecular sciences, 24 (2023), 1903, 19 doi:10.3390/ijms24031903 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1246441 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Protective effects of Arbutus unedo L. honey in
the
alleviation of irinotecan-induced cytogenetic
damage in
human lymphocytes—An in vitro study
(Protective effects of Arbutus unedo L. honey in
the alleviation of irinotecan-induced cytogenetic
damage in human lymphocytes—An in vitro study)
Autori
Jurič, Andreja ; Brčić Karačonji, Irena ; Gašić, Uroš ; Milojković Opsenica, Dušanka ; Prđun, Saša ; Bubalo, Dragan ; Lušić, Dražen ; Vahčić, Nada ; Kopjar, Nevenka
Izvornik
International journal of molecular sciences (1422-0067) 24
(2023);
1903, 19
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
chromosome aberration analysis ; Arbutus unedo ; cytokinesis-block micronucleus cytome assay ; honey ; irinotecan ; lymphocytes ; phenolics ; UHPLC-LTQ Orbitrap MS
Sažetak
Strawberry tree (Arbutus unedo L.) honey (STH) has been used since ancient times as a folk medicine remedy, especially in certain Mediterranean countries. This honey, rich in phenolic content, is well recognized for its antioxidant, anti- inflammatory, and antimicrobial activities, and is used for the treatment of skin lesions as well as gastrointestinal and respiratory disorders. This study investigated whether STH alleviates genome damage in human peripheral blood lymphocytes produced by the cytotoxic drug irinotecan. The phenolic profile of STH was previously estimated by ultra-high-performance liquid chromatography coupled to a linear ion trap–Orbitrap hybrid mass spectrometer. The effects of STH were evaluated at three concentrations (1x, 5x, and 10x), based on the daily consumption of the honey by an adult person. After 2 h of in vitro exposure, standard lymphocyte cultures for the analysis of chromosome aberrations and the cytokinesis-block micronucleus cytome assay were established. Our results demonstrate that STH offered remarkable geno- and cytoprotection when administered with irinotecan. These findings are relevant for drawing preliminary conclusions regarding the in vitro safety of the tested honey. However, further studies are needed with the application of more complex experimental models.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
Zaklada HAZU--10-1021-274-2020 - Biološki učinci meda obične planike (Arbutus unedo L.) na tumorske i zdrave ljudske stanice (Brčić Karačonji, Irena, Zaklada HAZU ) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Medicinski fakultet, Rijeka,
Agronomski fakultet, Zagreb,
Fakultet zdravstvenih studija u Rijeci
Profili:
Nevenka Kopjar
(autor)
Dražen Lušić
(autor)
Nada Vahčić
(autor)
Irena Brčić Karačonji
(autor)
Andreja Jurič
(autor)
Saša Prđun
(autor)
Dragan Bubalo
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE