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Pregled bibliografske jedinice broj: 1246277

Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis


Kovačić, Jelena; Jeličić, Mario-Livio; Amidžić Klarić, Daniela; Mornar, Ana
Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis // Separations, 10 (2023), 2; 69-87 doi:10.3390/separations10020069 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1246277 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis

Autori
Kovačić, Jelena ; Jeličić, Mario-Livio ; Amidžić Klarić, Daniela ; Mornar, Ana

Izvornik
Separations (2297-8739) 10 (2023), 2; 69-87

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
andrographolides ; bioanalysis ; sample preparation ; MEPS ; green analytical chemistry

Sažetak
Since inflammatory bowel disease is a progressive disease, optimal treatment early in the disease course is paramount. Still, the use of conventional drugs is accompanied by side effects. The herbal therapies for gastrointestinal disorders are traditionally widespread in Asia, while in Western countries have been adopted in recent years. Andrographis paniculata is a herbaceous plant used in anti￾inflammatory treatment. To improve its clinical application, an analytical method with the potential to define a relationship between dose and plasma concentration of active ingredients is prerequisite. Considering the increasing demand for eco-friendly bioanalytical methods, our research aimed to implement new sample preparation technique microextraction by packed sorbent for extraction of marker compounds of A. paniculata from plasma. This green procedure using polymeric sorbent based on the poly (styrene-divinylbenzene) allowed miniaturization of sample volume (100 µL), decrease in consumption of solvents, and high recovery (92–98%). A highly selective and sensitive reversed-phase ultrahigh-performance liquid chromatography method has been developed and validated. The newest greenness assessment software AGREE calculator was used for evaluation of the method’s environmental performance. It suggests that our method conforms to the eco- friendly conditions (score 0.8). The sample preparation was identified as weak point of the bioanalytical methods which highlights the importance of microextraction.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekti:
UIP-2017-05-3949 - Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva (IBDAnalytics) (Mornar Turk, Ana, HRZZ - 2017-05) ( CroRIS)
EK-EFRR-KK.01.1.1.02.0021 - Jačanje znanstveno-istraživačkih i inovacijskih kapaciteta Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu (FarmInova) (Lovrić, Jasmina, EK - Ulaganje u organizacijsku reformu i infrastrukturu u sektoru istraživanja, razvoja i inovacija) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Kovačić, Jelena; Jeličić, Mario-Livio; Amidžić Klarić, Daniela; Mornar, Ana
Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis // Separations, 10 (2023), 2; 69-87 doi:10.3390/separations10020069 (međunarodna recenzija, članak, znanstveni)
Kovačić, J., Jeličić, M., Amidžić Klarić, D. & Mornar, A. (2023) Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis. Separations, 10 (2), 69-87 doi:10.3390/separations10020069.
@article{article, author = {Kova\v{c}i\'{c}, Jelena and Jeli\v{c}i\'{c}, Mario-Livio and Amid\v{z}i\'{c} Klari\'{c}, Daniela and Mornar, Ana}, year = {2023}, pages = {69-87}, DOI = {10.3390/separations10020069}, keywords = {andrographolides, bioanalysis, sample preparation, MEPS, green analytical chemistry}, journal = {Separations}, doi = {10.3390/separations10020069}, volume = {10}, number = {2}, issn = {2297-8739}, title = {Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis}, keyword = {andrographolides, bioanalysis, sample preparation, MEPS, green analytical chemistry} }
@article{article, author = {Kova\v{c}i\'{c}, Jelena and Jeli\v{c}i\'{c}, Mario-Livio and Amid\v{z}i\'{c} Klari\'{c}, Daniela and Mornar, Ana}, year = {2023}, pages = {69-87}, DOI = {10.3390/separations10020069}, keywords = {andrographolides, bioanalysis, sample preparation, MEPS, green analytical chemistry}, journal = {Separations}, doi = {10.3390/separations10020069}, volume = {10}, number = {2}, issn = {2297-8739}, title = {Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis}, keyword = {andrographolides, bioanalysis, sample preparation, MEPS, green analytical chemistry} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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