Naslov
Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential

Autori
Vuić, Barbara ; Miloš, Tina ; Tudor, Lucija ; Konjevod, Marcela ; Nikolac Perković, Matea ; Jazvinšćak Jembrek, Maja ; Nedić Erjavec, Gordana ; Švob Štrac, Dubravka

Izvornik
Biomedicines (2227-9059) 10 (2022), 12; 3000, 31

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
neurodegenerative diseases ; proteinopathies ; endocannabinoid system ; cannabinoid CB2 receptors ; neuroinflammation ; therapy

Sažetak
Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate and adaptive immune systems and subsequently lead to chronic neuroinflammation that drives the onset and progression of neurodegenerative diseases. Since there is still no effective disease- modifying treatment, new therapeutic targets for neurodegenerative proteinopathies have been sought. The endocannabinoid system, and in particular the cannabinoid CB2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells. Several studies have shown promising effects of CB2 receptor activation on reducing protein aggregationbased pathology as well as on attenuating inflammation and several dementia- related symptoms. In this review, we discuss the available data on the role of CB2 receptors in neuroinflammation and the potential benefits and limitations of specific agonists of these receptors in the therapy of neurodegenerative proteinopathies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA