Pregled bibliografske jedinice broj: 1246022
PDGF inhibits BMP2-induced bone healing
PDGF inhibits BMP2-induced bone healing // npj Regenerative Medicine, 8 (2023), 1; 1-10 doi:10.1038/s41536-023-00276-5 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1246022 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
PDGF inhibits BMP2-induced bone healing
Autori
Novak, Sanja ; Madunic, Josip ; Shum, Laura ; Vucetic, Milan ; Wang, Xi ; Tanigawa, Hitoshi ; Ghosh, Mallika ; Sanjay, Archana ; Kalajzic, Ivo
Izvornik
Npj Regenerative Medicine (2057-3995) 8
(2023), 1;
1-10
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
bone defect ; bone morphogenetic protein 2 ; Platelet derived growth factor ; osteogenesis
Sažetak
Bone regeneration depends on a pool of bone/cartilage stem/progenitor cells and signaling mechanisms regulating their differentiation. Using in vitro approach, we have shown that PDGF signaling through PDGFRβ inhibits BMP2-induced osteogenesis, and significantly attenuates expression of BMP2 target genes. We evaluated outcomes of treatment with two anabolic agents, PDGF and BMP2 using different bone healing models. Targeted deletion of PDGFRβ in αSMA osteoprogenitors, led to increased callus bone mass, resulting in improved biomechanical properties of fractures. In critical size bone defects BMP2 treatment increased proportion of osteoprogenitors, while the combined treatment of PDGF BB with BMP2 decreased progenitor number at the injury site. BMP2 treatment induced significant bone formation and increased number of osteoblasts, while in contrast combined treatment with PDGF BB decreased osteoblast numbers. This is in vivo study showing that PDGF inhibits BMP2- induced osteogenesis, but inhibiting PDGF signaling early in healing process does not improve BMP2-induced bone healing.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus