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Pregled bibliografske jedinice broj: 1246022

PDGF inhibits BMP2-induced bone healing


Novak, Sanja; Madunic, Josip; Shum, Laura; Vucetic, Milan; Wang, Xi; Tanigawa, Hitoshi; Ghosh, Mallika; Sanjay, Archana; Kalajzic, Ivo
PDGF inhibits BMP2-induced bone healing // npj Regenerative Medicine, 8 (2023), 1; 1-10 doi:10.1038/s41536-023-00276-5 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1246022 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
PDGF inhibits BMP2-induced bone healing

Autori
Novak, Sanja ; Madunic, Josip ; Shum, Laura ; Vucetic, Milan ; Wang, Xi ; Tanigawa, Hitoshi ; Ghosh, Mallika ; Sanjay, Archana ; Kalajzic, Ivo

Izvornik
Npj Regenerative Medicine (2057-3995) 8 (2023), 1; 1-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone defect ; bone morphogenetic protein 2 ; Platelet derived growth factor ; osteogenesis

Sažetak
Bone regeneration depends on a pool of bone/cartilage stem/progenitor cells and signaling mechanisms regulating their differentiation. Using in vitro approach, we have shown that PDGF signaling through PDGFRβ inhibits BMP2-induced osteogenesis, and significantly attenuates expression of BMP2 target genes. We evaluated outcomes of treatment with two anabolic agents, PDGF and BMP2 using different bone healing models. Targeted deletion of PDGFRβ in αSMA osteoprogenitors, led to increased callus bone mass, resulting in improved biomechanical properties of fractures. In critical size bone defects BMP2 treatment increased proportion of osteoprogenitors, while the combined treatment of PDGF BB with BMP2 decreased progenitor number at the injury site. BMP2 treatment induced significant bone formation and increased number of osteoblasts, while in contrast combined treatment with PDGF BB decreased osteoblast numbers. This is in vivo study showing that PDGF inhibits BMP2- induced osteogenesis, but inhibiting PDGF signaling early in healing process does not improve BMP2-induced bone healing.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Ivo Kalajzić (autor)

Avatar Url Sanja Novak (autor)

Avatar Url Josip Madunić (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.nature.com

Citiraj ovu publikaciju:

Novak, Sanja; Madunic, Josip; Shum, Laura; Vucetic, Milan; Wang, Xi; Tanigawa, Hitoshi; Ghosh, Mallika; Sanjay, Archana; Kalajzic, Ivo
PDGF inhibits BMP2-induced bone healing // npj Regenerative Medicine, 8 (2023), 1; 1-10 doi:10.1038/s41536-023-00276-5 (međunarodna recenzija, članak, znanstveni)
Novak, S., Madunic, J., Shum, L., Vucetic, M., Wang, X., Tanigawa, H., Ghosh, M., Sanjay, A. & Kalajzic, I. (2023) PDGF inhibits BMP2-induced bone healing. npj Regenerative Medicine, 8 (1), 1-10 doi:10.1038/s41536-023-00276-5.
@article{article, author = {Novak, Sanja and Madunic, Josip and Shum, Laura and Vucetic, Milan and Wang, Xi and Tanigawa, Hitoshi and Ghosh, Mallika and Sanjay, Archana and Kalajzic, Ivo}, year = {2023}, pages = {1-10}, DOI = {10.1038/s41536-023-00276-5}, keywords = {bone defect, bone morphogenetic protein 2, Platelet derived growth factor, osteogenesis}, journal = {npj Regenerative Medicine}, doi = {10.1038/s41536-023-00276-5}, volume = {8}, number = {1}, issn = {2057-3995}, title = {PDGF inhibits BMP2-induced bone healing}, keyword = {bone defect, bone morphogenetic protein 2, Platelet derived growth factor, osteogenesis} }
@article{article, author = {Novak, Sanja and Madunic, Josip and Shum, Laura and Vucetic, Milan and Wang, Xi and Tanigawa, Hitoshi and Ghosh, Mallika and Sanjay, Archana and Kalajzic, Ivo}, year = {2023}, pages = {1-10}, DOI = {10.1038/s41536-023-00276-5}, keywords = {bone defect, bone morphogenetic protein 2, Platelet derived growth factor, osteogenesis}, journal = {npj Regenerative Medicine}, doi = {10.1038/s41536-023-00276-5}, volume = {8}, number = {1}, issn = {2057-3995}, title = {PDGF inhibits BMP2-induced bone healing}, keyword = {bone defect, bone morphogenetic protein 2, Platelet derived growth factor, osteogenesis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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