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Pregled bibliografske jedinice broj: 1244768

The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD


Radmanić, Leona; Zidovec-Lepej, Snježana
The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD // Life, 12 (2022), 2072, 16 doi:10.3390/life12122072. (međunarodna recenzija, članak, znanstveni)


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Naslov
The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD

Autori
Radmanić, Leona ; Zidovec-Lepej, Snježana

Izvornik
Life (2075-1729) 12 (2022); 2072, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
growth factors ; liver disease ; SCF ; EGF ; Ang-2

Sažetak
Growth factors play a significant role in the immunopathogenesis of liver diseases, especially in liver fibrosis and cirrhosis. They can also play a role in liver regeneration and tissue repair. The regenerative capacity of the liver has been well established. Molecular mechanisms leading to regeneration involve a complex network of diverse molecules. Chronic liver injury leads to the dysregulation of regenerative mechanisms in the liver that, in addition to molecular oncogenesis, lead to uncontrolled cell proliferation and development of hepatocellular carcinoma (HCC). Stem cell factor (SCF), epidermal growth factor (EGF) and Angiopietin-2 (Ang-2) have been shown to be extremely important in the pathogenesis of liver diseases, and given their role in hepatitis B (HBV) or C virus (HCV), HCC and nonalcoholic fatty liver disease (NAFLD), they seem to be potential targets for future research into antifibrotic drugs. The role of SCF receptor c-kit in the liver is debatable, as it has impact on both liver regeneration and liver disease. EGF is a potential indicator of the survival of patients with HCC and can be a biomarker and therapeutic target structure in HCC. Further research is needed to investigate the potential role of Ang-2 for NAFLD associated with liver damage as a non-invasive circulating biomarker.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
UIP-2019-04-7194 - Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi (SepsisFAT) (Papić, Neven, HRZZ - 2019-04) ( CroRIS)
EK-KK.01.1.1.01.0006 - Jačanje kapaciteta CERVIRVAC-a za istraživanja u virusnoj imunologiji i vakcinologiji (Jonjić, Stipan, EK ) ( CroRIS)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Radmanić, Leona; Zidovec-Lepej, Snježana
The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD // Life, 12 (2022), 2072, 16 doi:10.3390/life12122072. (međunarodna recenzija, članak, znanstveni)
Radmanić, L. & Zidovec-Lepej, S. (2022) The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD. Life, 12, 2072, 16 doi:10.3390/life12122072..
@article{article, author = {Radmani\'{c}, Leona and Zidovec-Lepej, Snje\v{z}ana}, year = {2022}, pages = {16}, DOI = {10.3390/life12122072.}, chapter = {2072}, keywords = {growth factors, liver disease, SCF, EGF, Ang-2}, journal = {Life}, doi = {10.3390/life12122072.}, volume = {12}, issn = {2075-1729}, title = {The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD}, keyword = {growth factors, liver disease, SCF, EGF, Ang-2}, chapternumber = {2072} }
@article{article, author = {Radmani\'{c}, Leona and Zidovec-Lepej, Snje\v{z}ana}, year = {2022}, pages = {16}, DOI = {10.3390/life12122072.}, chapter = {2072}, keywords = {growth factors, liver disease, SCF, EGF, Ang-2}, journal = {Life}, doi = {10.3390/life12122072.}, volume = {12}, issn = {2075-1729}, title = {The Role of Stem Cell Factor, Epidermal Growth Factor and Angiopoietin-2 in HBV, HCV, HCC and NAFLD}, keyword = {growth factors, liver disease, SCF, EGF, Ang-2}, chapternumber = {2072} }

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