Naslov
Synthesis of Glycine and Phenylalanine Containing Cyclopeptides and their Anion Binding Properties in Acetonitrile

Autori
Duvnjak, Mirko ; Talajić, Gregor ; Modrušan, Matija ; Petrović Hađar, Emilija ; Horvat, Gordan ; Cindro, Nikola ; Tomišić, Vladislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
5. simpozij supramolekulske kemije

Mjesto i datum
Zagreb, Hrvatska, 08.12.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cyclopeptide ; anion binding ; acetonitrile

Sažetak
In the last few decades cyclic peptides have become compounds of interest due to their potential biological activity as well as their ability to act as molecular recepors.1-2 Cyclic peptides are especially attractive as biologically active compounds due to their increased bioavailability and metabolic stability. To gain further insight into the reactivity and anion binding properties of cyclopeptides we synthesized three peptides, tetrapeptide Phe-Phe-Gly-Gly 1, pentapeptide Phe-Phe-Gly-Gly-Phe 2 and hexapeptide Phe-Phe-Gly-Gly-Phe-Phe 3 using solution-based synthesis. The cyclization of this linear oligopeptides was then explored using a chloride- assisted macrocyclization reaction recently developed in our group3 enabling the synthesis of C2 and C3 while the tetrapeptide 1 failed to cyclize. The complexation affinity of C2 and C3 towards both cations and anions in acetonitrile was studied using fluorescence spectroscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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