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Pregled bibliografske jedinice broj: 1244368

Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes


Gašparini, Dora; Kavazović, Inga; Barković, Igor; Maričić, Vitomir; Ivaniš, Viktor; Samsa, Dijana Travica; Peršić, Viktor; Polić, Bojan; Turk Wensveen, Tamara; Wensveen, Felix M.
Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes // Immunology letters, 248 (2022), 45-55 doi:10.1016/j.imlet.2022.06.001 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1244368 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes

Autori
Gašparini, Dora ; Kavazović, Inga ; Barković, Igor ; Maričić, Vitomir ; Ivaniš, Viktor ; Samsa, Dijana Travica ; Peršić, Viktor ; Polić, Bojan ; Turk Wensveen, Tamara ; Wensveen, Felix M.

Izvornik
Immunology letters (0165-2478) 248 (2022); 45-55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytokines ; cytotoxicity ; diving ; exercise ; hypoxia ; lymphocytes ; sport

Sažetak
Exercise has many beneficial effects for our body, but can become detrimental at high intensity, especially for our immune system. Little is known about the underlying mechanism of impaired immune functionality under conditions of intense physical strain. Freedivers, people who dive to high depths on a single breath, perform extreme exercise under anaerobic conditions. In this study, we investigated the impact of freediving on the cytotoxic arm of the immune system. At rest, elite freedivers did not display changes in their immunological profile compared to non-diving controls. In contrast, after a freedive, granzyme B and IL-2 production were reduced, whereas IFNγ and TNF secretion were increased by cytotoxic immune cells. Using in vitro models mimicking freedive conditions, we could show that hypoxia in combination with stress hyperglycemia had a negative impact on Granzyme B secretion, whereas IL-2 production was inhibited by stress hormones. Our findings suggest that in response to extreme exercise, cytotoxic immune cells transiently change their functional profile to limit tissue damage

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
--IP-2020-02-7928 - Utjecaj šećerne bolesti tipa 2 i njezinog liječenja na funkciju limfocita (DIABOLYC) (Turk Wensveen, Tamara) ( CroRIS)
HRZZ-IP-2016-06-8027 - Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva (T-MEMORY) (Wensveen, Felix Martinus, HRZZ - 2016-06) ( CroRIS)
HRZZ-IP-CORONA-2020-04-2045 - Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja (CORONAWAI) (Wensveen, Felix Martinus, HRZZ - 2020-04) ( CroRIS)
HRZZ-IP-2016-06-9306 - Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini (INFLAMETAB) (Polić, Bojan, HRZZ - 2016-06) ( CroRIS)
HRZZ-IPCH-2020-10-8440 - Mehanizmi imunološkog prepoznavanja u jetri i njihova uloga u razvoju nealkoholnog steatohepatitisa (MITRAS) (Polić, Bojan, HRZZ - IPCH-2020-10) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Thalassoterapia Opatija

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Gašparini, Dora; Kavazović, Inga; Barković, Igor; Maričić, Vitomir; Ivaniš, Viktor; Samsa, Dijana Travica; Peršić, Viktor; Polić, Bojan; Turk Wensveen, Tamara; Wensveen, Felix M.
Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes // Immunology letters, 248 (2022), 45-55 doi:10.1016/j.imlet.2022.06.001 (međunarodna recenzija, članak, znanstveni)
Gašparini, D., Kavazović, I., Barković, I., Maričić, V., Ivaniš, V., Samsa, D., Peršić, V., Polić, B., Turk Wensveen, T. & Wensveen, F. (2022) Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes. Immunology letters, 248, 45-55 doi:10.1016/j.imlet.2022.06.001.
@article{article, author = {Ga\v{s}parini, Dora and Kavazovi\'{c}, Inga and Barkovi\'{c}, Igor and Mari\v{c}i\'{c}, Vitomir and Ivani\v{s}, Viktor and Samsa, Dijana Travica and Per\v{s}i\'{c}, Viktor and Poli\'{c}, Bojan and Turk Wensveen, Tamara and Wensveen, Felix M.}, year = {2022}, pages = {45-55}, DOI = {10.1016/j.imlet.2022.06.001}, keywords = {cytokines, cytotoxicity, diving, exercise, hypoxia, lymphocytes, sport}, journal = {Immunology letters}, doi = {10.1016/j.imlet.2022.06.001}, volume = {248}, issn = {0165-2478}, title = {Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes}, keyword = {cytokines, cytotoxicity, diving, exercise, hypoxia, lymphocytes, sport} }
@article{article, author = {Ga\v{s}parini, Dora and Kavazovi\'{c}, Inga and Barkovi\'{c}, Igor and Mari\v{c}i\'{c}, Vitomir and Ivani\v{s}, Viktor and Samsa, Dijana Travica and Per\v{s}i\'{c}, Viktor and Poli\'{c}, Bojan and Turk Wensveen, Tamara and Wensveen, Felix M.}, year = {2022}, pages = {45-55}, DOI = {10.1016/j.imlet.2022.06.001}, keywords = {cytokines, cytotoxicity, diving, exercise, hypoxia, lymphocytes, sport}, journal = {Immunology letters}, doi = {10.1016/j.imlet.2022.06.001}, volume = {248}, issn = {0165-2478}, title = {Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes}, keyword = {cytokines, cytotoxicity, diving, exercise, hypoxia, lymphocytes, sport} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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